The Dutchman bowed out of his career at the Emirates with the PFA Player of the Year award, Golden Boot and the captain's armband. His subsequent Old Trafford switch finally secured him the Premier League title and another top scorer award at that.
All that considered, Van Persie's fall from the top was far more abrupt than people remember.
The retirement of Sir Alex Ferguson pulled the rug from underneath his time with United as seasons under David Moyes and Louis van Gaal undercut his goal scoring.
Now at age 34, Van Persie is entering his third season with Fenerbahce in Turkey as he winds out his career under the radar.
It's now a distant half-decade since the RVP's zenith and that monstrous 30-goal season with Arsenal. The Dutchman managed to inspire an Arsenal side that had been drubbed 8-2 at Old Trafford to an eventual third place finish.
Accolades and memories aren't all Van Persie took from his time at Arsenal, though.
Besides, the 34-year-old has maintained a frosty relationship with one of his old Arsenal teammates and - according to The Sun - they now refuse to speak to one another.
The man in question is, of all people, Oguzhan Ozyakup.
The Turkish international became close pals with Van Persie during their time at Arsenal, eventually leaving for Besiktas in 2012 after first-team opportunities dried up. Three-years later and RVP arrived in Istanbul, too, but for a rival club.
Come last season and during a derby match between the two sides, Van Persie and Ozyakup were seen shouting and shoving each other as the fixture boiled over.
Then, when RVP scored the winning goal, he proceeded to celebrate by knee-sliding right to the feet of his ex-Arsenal buddy.
Ozyakup icily stated after the game: "I was very good friends with a certain player on the field. That changed today.
"Sometimes you see the real face of a footballer on the field."
And now, seven months down the line, the pair still don't see eye-to-eye.
The two sides will next meet on February 25 at the Vodafone Stadium where, let's just say, Van Persie could get an interesting reception.
Do you think Robin van Persie would still cut it in the Premier League? Have your say in the comments section below.