Arsenal will welcome back England forward Theo Walcott and Brazilian midfielder Denilson from injury for the Barclays Premier League clash against Bolton at Emirates Stadium.
However, Fran Merida - who scored the second goal in Sunday's win over the Trotters - missed out with an ankle problem, while Aaron Ramsey (thigh) and Samir Nasri (hamstring) are also both sidelined.
Veteran defender Sol Campbell will need another week's training before being in first-team contention after officially rejoining the club.
Alex Song and Emmanuel Eboue are away at the African Nations Cup, while Nicklas Bendtner (groin), Kieran Gibbs (foot), Robin van Persie (ankle) and Johan Djourou (knee) remain out.
Arsene Wenger is hoping Arsenal's continuing cycle of injuries does not derail their Barclays Premier League title bid.
The Gunners could go top of the table with victory over struggling Bolton.
Captain Cesc Fabregas marked his return from a three-week lay-off with the opening goal at the Reebok Stadium on Sunday, while match-fit England forward Theo Walcott and Denilson are set to feature again on Wednesday.
However, both Ramsey and Nasri are expected to be out for the best part of a month after picking up injuries in training last week, while Merida suffered an ankle problem just before he scored Arsenal's late second goal at Bolton.
Denmark striker Nicklas Bendtner should, though, be back in contention for the trip to Aston Villa on January 27 as he recovers from groin surgery.
Wenger said: "We have analysed absolutely everything.
"It is strange because the more injuries you get, you then seem to get even more because you always play the same players.
"Also, you rush some players back and then you have more chance to get them injured again."
Owen Coyle has an almost fully-fit squad to choose from as Bolton prepare to take on Arsenal for the second time in four days.
With his players having come through the first game against the Gunners - and Coyle's first in charge - on Sunday without suffering any injuries, the manager is only missing Dan Shittu in the short-term, who is away with Nigeria at the African Nations Cup.
Long-term injury victims Joey O'Brien and Sean Davis (both knee) are the other players who will not be available for the trip to the Emirates Stadium.
Coyle has praised Arsene Wenger for getting Arsenal's title challenge back on track and believes the Gunners can win the Barclays Premier League this season.
Following their 2-0 victory at the Reebok Stadium on Sunday, a win for Wenger's team could take them above current leaders Chelsea to the top of the table.
It would mark quite a feat for the Gunners, who trailed Chelsea by 11 points in November after being beaten 3-0 by the Blues at the Emirates Stadium.
Since then Arsenal have gone eight games unbeaten in the league and, with the momentum building, Coyle believes they could well be champions come May.
Asked if he thought Arsenal were genuine title contenders, Coyle said: "They are, absolutely, and I think it's all credit to them.
"They are title challengers after not even just being written off - they were totally dismissed. I think they went 11 points behind at one stage and all credit to Arsenal and Arsene. He has galvanised them.
"They have had horrendous injuries to strikers, they have changed their forward line.
"People think they have an unconventional forward line with smaller types but their movement and their ability speaks for itself.
"So yes, they will be there until the end of the season, I've no doubt about it, and have a real chance of winning it."
Copyright (c) PA Sport 2009, All Rights Reserved.
Do YOU want to write for GiveMeSport? Get started today by signing-up and submitting an article HERE: https://www.givemesport.com/writeforgms