Heading into the clash at Anfield, Jose Mourinho's men have yet to face any of the top six sides in the Premier League, with their hardest game coming against Stoke City away.
It's against Liverpool that United will really show what they're made of given the fixture is steeped in history.
Very few rivalries compare in English football. For years Liverpool dominated, especially throughout the 1970s and 1980s, but United soon clawed their way back.
Sir Alex Ferguson's arrival as manager in 1986 sparked a resurgence that eventually saw United win their 19th English title and break Liverpool's record of 18 in 2011.
As for the here and now, both clubs are vying to relive their glory days by winning the 2017/18 title, although United look more on course to do that.
The Red Devils are currently joint top in the Premier League with Manchester City on 19 points, while Liverpool languish in seventh on 12.
Recent form is in United's favour, too, given they're unbeaten in seven league games and have only conceded twice.
Liverpool, on the other hand, have won only once in their last four games and currently boast a meagre goal difference of +1.
Form pales into insignificance when it comes to games between Liverpool and United on Merseyside, though, because anything can happen at Anfield.
'Unpredictable' best summarises Saturday's fixture and now Gary Pallister has told a hilarious story about what happened to Gary Neville and David Beckham when they first played at Anfield.
Back in 1995, Neville started and Beckham came on as a substitute in a 2-2 draw. Nicky Butt and Eric Cantona were the scorers for United.
But after the game, the English duo were subjected to humiliation by two seven-year-old Liverpool fans posing as autograph hunters.
"The funniest thing that I remember was being there when it was Becks (Beckham) and Gary Neville's first game at Anfield and two little Scouser lads went over," Pallister told Betsafe.
"They must've been six or seven-years-old, and they asked for their autograph.
"Neville and Becks were quite chuffed to have been asked and then the lads ripped it up in front of them."
How brutal is that? Football fans can be cruel, but who knew a couple of seven-year-olds could be capable of something so humiliating?