Both sides are in good form heading into the clash and currently joint top of Group H, having won their opening two games, scored six goals and conceded one.
But the pressure is on Real out of the two. Zinedine Zidane's men are not only the hosts, but reigning champions, so the expectation is on them.
That's not to say Spurs can't get a result in the Spanish capital, though, and Graeme Souness believes they must play it smart to come away with anything.
"I would think he (Pochettino) will go with a more defensive head on," he said. "Be solid to begin with, do not go behind early and allow them to get their tails up.
"Go there, have a look and see what Real Madrid throw at them. Tottenham are wise enough now to do that.
"Real are arguably the best counter attacking team in the world with the pace they have, but I think Tottenham can get a result."
Maurcio Pochettino will be without Dele Alli and Ben Davies for the trip but welcomes back Mousa Dembele and Jan Vertonghen after suspension.
It really is anyone's guess how Spurs will line-up, which is what makes the Spanish press' predictions all the more hilarious.
In the tweets below, Marca and an unknown Spanish newspaper have released their predicted starting XI's and they're nothing short of bizarre.
Marca think Tottenham will use a 4-4-2 formation against Real which includes Dembele playing on the right, Davinson Sanchez playing in midfield and Serge Aurier at left-back.
As we know, Dembele is a central midfielder, summer signing Sanchez is a centre-back and Aurier is naturally a right-back.
SPANISH NEWSPAPER'S LINE-UP
As for the other Spanish source, they've used Davies - who isn't even available - upfront, Son Heung-min at right-back, Vertonghen at left-back and Kieran Tripper at centre-back.
And let's not get started on Kane at No.10 and Alli, who is banned and can't even play against Real.
Safe to say Tottenham's line-up will look nothing like what the Spanish press say, although Davies as striker has to be an accident.
AS have also had a go at predicting how Spurs will look at the Bernabeu and it seems a lot more accurate.