Exeter will be without Troy Archibald-Henville as they bid to bounce back from derby defeat at Yeovil when they host Carlisle.
The on-loan central defender has returned to parent club Tottenham following the end of his loan spell at Exeter and will not feature, leaving boss Paul Tisdale with a potential defensive crisis.
Fellow defender Rob Edwards was ruled out of the 2-1 Huish Park defeat following a facial injury sustained in the 2-0 home win over Leeds and unless he makes a quicker than expected recovery, he is also likely to miss the clash.
City only have one recognised central defender in skipper Matt Taylor, although Richard Duffy played in a back three alongside Taylor and Archibald-Henville on Saturday and is expected to do the same again.
The Grecian's only other recognised central defender Scot Bennett, who is on loan at Weymouth.
Carlisle will be without suspended striker Scott Dobie.
Dobie was sent off following an incident involving Stockport defender Danny Swailes in Saturday's goalless draw at Brunton Park and starts a three-game ban.
Cumbrians manager Greg Abbott will have fellow forwards Joe Anyinsah, Richard Offiong and Gary Madine to choose from, but is considering bringing another striker in on loan to cover for Dobie's absence after the recent departure of Vincent Pericard.
Skipper Paul Thirlwell will be hoping to be involved against Exeter after recently returning to the squad following an Achilles injury.
Thirlwell and Marc Bridge-Wilkinson were both unused substitutes on Saturday, while Madiner and Offiong, recovered from a recent knee injury, stepped off the bench late in the game.
David Raven (hip), Andy Cook (foot) and Gavin Rothery (double hernia) remain sidelined.
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