Colchester boss Aidy Boothroyd is set to name an unchanged side for the visit of Brentford.
The Us ran out narrow 1-0 winners over struggling Oldham on Saturday thanks to a Danny Batth second-half header.
On-loan striker Kevin Lisbie was a 75th-minute substitute in that game after he had missed the last four outings with a thigh injury, and he is again poised to start from the bench.
Defender Christian Ribeiro, who has missed the last six games with a groin injury, remains out.
Midfielder Ashley Vincent was only deemed fit enough for a place on the bench against the Latics following his lengthy spell on the sidelines since September with an ankle injury.
Centre-back Lee Beevers, who recently recovered from a long-term shoulder injury, has picked up a knee problem and will miss out.
Brentford boss Andy Scott is boosted by the news Marcus Bean is poised to return to first-team duties.
The defender missed the 1-1 draw against Wycombe with a knee injury and was only deemed fit enough for a place on the bench in their 2-1 defeat by Walsall on Saturday.
Striker Charlie McDonald is assured of a starting berth after he notched his 10th goal of the campaign against the Saddlers.
However, defender Ryan Dickson remains a major doubt after he missed the weekend clash with a knee injury, so loanee Tommy Smith is likely to retain his place in the side.
Lionel Ainsworth is still awaiting his full debut since joining on loan from League One rivals Huddersfield, and having made three substitute appearances will push Sam Saunders for a starting berth.
Goalkeeper Nikki Bull remains sidelined with a shoulder injury.
Copyright (c) PA Sport 2009, All Rights Reserved.
Do YOU want to write for GiveMeSport? Get started today by signing-up and submitting an article HERE: https://www.givemesport.com/writeforgms