Bolton manager Owen Coyle has Vladimir Weiss and Jack Wilshere back for his squad to face Wolves after the on-loan duo were cup-tied for the midweek defeat at Tottenham.
Defender Gretar Steinsson may be available having returned to training from injury, but Mark Davies is still sidelined. Gavin McCann, Chris Basham, Joey O'Brien and Sean Davis are long-term absentees, but there is positive news regarding Gary Cahill.
Cahill's season was feared to be over after a blood clot was discovered in the defender's arm earlier this month, but Coyle has confirmed that having undergone an operation, the defender could be back in action within four weeks.
With Wolves themselves only two places and one point above Bolton, Saturday's game is one of a series of crucial six-pointers Wanderers face in the weeks to come.
The defeat to FA Cup to Tottenham will allow Coyle's side to focus on their bid for Premier League survival, but the manager views each of their remaining fixtures as "cup finals" anyway in terms of their significance and is looking for nothing short of victory in every one.
"We talk about going out of the cup, but we have now got 12 cup finals, there is no doubt about it," Coyle said.
"We are all in the same boat, a group of teams including ourselves and our opponents tomorrow Wolves.
"Really, in every game we will be going out to get the maximum three points, and tomorrow will be no different.
"It is a massive game for both teams but we are at home, we have been doing terrific at the Reebok, and we have to look to continue that.
"It will be a tough game but it is one we are looking forward to. The players have to go and give their maximum and if we do that, it can result in a very positive day."
Wolves are boosted by the surprise return of striker Andy Keogh.
Keogh has been sidelined since undergoing ankle surgery in December when he fell awkwardly in training, however he is in contention to be on the bench.
Wolves also welcome on-loan utility player Michael Mancienne back into the squad after he missed last weekend's 2-0 defeat against his parent club, Chelsea.
Manager Mick McCarthy has confirmed he will retain the starting line-up that faced Chelsea.
McCarthy argues that there is more pressure on Bolton in this six-pointer.
"Clearly the emphasis will be on them to win as it is their home game," added McCarthy.
"Their fans will be turning up and seeing this as an opportunity to get three points and to get above Wolves. It is not just as easy as that.
"We have to stay in the game and not go there thinking that three points is a must and lose the game.
"We will be trying to get three points but if I come away with a point it will be as valuable as any we get this season.
"Neither of us will be settling for a point but if we came away and the status quo between us remained the same, then I will take that. It is about staying amongst it, not getting cut adrift."
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