Preston winger Paul Parry has suffered an injury setback ahead of the home clash with his former club Cardiff.
The summer signing from the Bluebirds has been sidelined since December with a tendonitis injury which now requires a long period of rehabilitation.
Boss Darren Ferguson said: "He's not so good, he's gone back a little bit.
"With Paul I don't know if he will be fit again this season.
"He saw the specialist last week and his opinion is that he needs more rest and longer rehab for it to get right."
Skipper Callum Davidson has missed the last seven games through injury and looks set to remain sidelined, but midfielder Richard Chaplow is available again.
Chaplow has missed the last five matches with a groin problem.
Cardiff boss Dave Jones has a concern over Darcy Blake.
The midfielder is struggling with a virus and is rated doubtful for the clash at Deepdale, while striker Warren Feeney may also miss out as his wife is due to give birth in the near future.
But Aaron Wildig and Anthony Gerrard have recovered from the injuries they picked up in last weekend's defeat against Barnsley.
The Bluebirds are still keeping an eye on goalkeeper David Marshall, who has been struggling with a medial ligament problem, so Peter Enckelman is again likely to start between the sticks.
Stephen McPhail (ribs) may return next month, while Joe Ledley (hips) has a slight chance of coming back before the end of the season.
Mark Hudson (ankle), Miguel Comminges (thigh) and Josh Magennis (broken fibula) remain sidelined, while the Bluebirds are keeping in touch with Manchester City over the fitness of on-loan forward Kelvin Etuhu (ankle).
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