Deon Burton, Jonjo Shelvey and Jose Semedo are injury doubts ahead of Charlton's home game against Stockport.
Boss Phil Parkinson will make a late decision on top scorer Burton after the striker had an injection in his groin earlier in the week.
Teenage playmaker Shelvey took a whack to his ankle in training on Thursday and fellow midfielder Semedo has been struggling with a virus.
Parkinson is still without left-backs Kelly Youga (knee) and Grant Basey (ankle) so on loan Notts County midfielder Johnnie Jackson continues to fill in.
Goalkeeper Rob Elliot gifted Southend a goal during Charlton's 2-1 win at Roots Hall last time out, but Parkinson is set to keep faith with his number one.
Stockport boss Gary Ablett will be without midfielder David Poole for the daunting trip.
Poole was sent off for the second time this season in Tuesday`s 1-0 defeat at Bristol and now serves a two-match ban.
Ablett looks certain to be without striker Jemal Johnson after he was substituted against the Pirates after picking up a hamstring injury.
He was replaced after just 39 minutes by former Liverpool winger Ritchie Partridge, who could now be handed a starting role.
Johnny Mullins is a doubt with an ankle injury and could miss out again, but fellow defender Danny Swailes is expected to shake off a dead leg and be passed fit.
County have won two of their last four matches but remain rock-bottom of League One.
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