Lille winger Eden Hazard's late goal inflicted Liverpool's first defeat on French soil in six visits and left Rafael Benitez's side with an uphill battle to make the quarter-finals of the Europa League following a 1-0 loss.
The visitors appeared to have survived a testing examination by Les Dogues only for Hazard - who had been a threat all night - to curl in an 85th-minute free-kick.
Despite being territorially dominated Liverpool had the best two chances with Ryan Babel shooting too close to Mickael Landreau and Fernando Torres' header being brilliantly saved by the goalkeeper in the first half.
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