Jose Mourinho's Manchester United side were held to a 2-2 draw at home to Burnley to end any lingering hopes of catching Manchester City.
The visitors took the lead within three minutes through Ashley Barnes and doubled their advantage through a brilliant Steven Defour free kick.
Jesse Lingard came off the bench at half-time and scored a brace to rescue a point at home to Sean Dyche's side.
However, it was a costly draw and Pep Guardiola's Manchester City will be able to create a 15-point gap by beating Newcastle on Wednesday night.
The Red Devils face Southampton and Everton over the next week and they'll need to rediscover their form or else they'll find themselves in the battle for top four.
Jesse Lingard was certainly Manchester United's standout performer but the unhappy fans were turning their attention to another young academy star.
United fans slam one player
Marcus Rashford has been disappointing in recent weeks and has found himself behind Anthony Martial in the pecking order.
The 20-year-old forward was recalled to Mourinho's XI at home to Burnley, with Martial left out of the matchday squad due to a reported injury.
Rashford continued his poor form at Old Trafford on Boxing Day and, despite his age, fans were giving him plenty of stick on social media.
The young academy graduate had better improve soon or he could find himself frozen out by his Portuguese coach.
Former Manchester United midfielder Paul Ince singled out Rashford for criticism in the wake of last week's shock 2-1 Carabao Cup defeat to Bristol City.
"I kept seeing Marcus Rashford attempt little flicks in the middle of the park, and it seems to me as though he has gotten ahead of himself," said Ince.
"He’s a fantastically talented player – but right then, against Bristol who really wanted the win, wasn’t the time.
"He should’ve been focused on doing absolutely anything he could to help the team, rather than showboating."