Radhi Jaidi will be missing from the Southampton line-up for the visit of Charlton.
The Tunisian centre-half suffered a torn hamstring during the opening five minutes of Monday's win over Leyton Orient and was replaced by Dan Seaborne.
Jaidi is expected to be out for a fortnight so Seaborne is in line to start with veteran Chris Perry returning to the bench.
Fellow defender Wayne Thomas is still recovering from a calf injury but should be back in training next week.
Striker David Connolly could be among the substitutes after missing the last two games for personal reasons.
Winger Lee Holmes is edging closer to fitness after a month out with a groin injury but full-back Graeme Murty is still sidelined with ankle ligament damage.
Nicky Bailey is pushing to return to the Charlton line-up.
The skipper was only fit enough to start on the bench against Carlisle on Easter Monday as he was still feeling an ankle injury.
Bailey could come in on the left flank in place of Kyel Reid or in central midfield with Therry Racon or Jose Semedo making way.
Semedo faces a two-match ban if he is booked at St Mary's so he could be the man to make way.
Rob Elliot (groin) is still out so Darren Randolph continues in goal while full-backs Grant Basey (ankle) and Kelly Youga (knee) and striker Leon McKenzie (thigh) remain on the sidelines.
Frontman Deon Burton (groin) is still a doubt so Jonjo Shelvey, who was given his Charlton debut as a 16-year-old by Pardew, should partner 36-year-old Nicky Forster in attack once more.
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