Derby forward Steve Davies will undergo ankle surgery and duo Rob Hulse and Kris Commons are also set to miss the rest of the season due to hamstring injuries.
"Steven will have an operation and that's him done for the season now," said manager Nigel Clough.
On Hulse and Commons, he added: "Unless Rob and Kris Commons are 100%, it is not worth risking them."
Davies has endured another injury-ravaged campaign, starting only seven league matches and featuring in just 22 of the Rams` 49 fixtures in all competitions. He has started only 20 games since his arrival from Tranmere in the summer of 2008.
Davies, Commons and Hulse will miss the final two games at Bristol City and against Cardiff at Pride Park, although Derby's Championship survival is now guaranteed following the 1-1 draw with Crystal Palace on Saturday.
Clough added: "Steven has this thing on his ankle, possibly from the Plymouth game, and will be out for between four and six weeks."
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