Morgan Schneiderlin and Wayne Thomas will be missing from the Southampton squad which hosts Carlisle.
Midfielder Scneiderlin serves the second game of the four-match suspension which has ended his season unless Saints finish in the play-offs.
Defender Thomas is making good progress from a calf injury but is not ready to be risked.
Veteran full-back Graeme Murty is the only other injury absentee following ankle surgery.
Boss Alan Pardew could make changes following the disappointing goalless draw against Oldham on Tuesday night, and he has plenty of options.
Paul Wotton replaced Schneiderlin in midweek but was withdrawn at half-time in favour of Lloyd James, and he could start against a Carlisle side who were beaten by Saints 4-1 in the Johnstone's Paint Trophy final last month.
Carlisle will monitor the fitness of Jason Price.
The on-loan Millwall striker has missed the last two games due to a hamstring strain and will have to prove his fitness if he is to earn a place in the squad.
David Raven will be hoping to retain his place in the side after making his first start in six months in last weekend's 2-1 home defeat by Oldham.
Danny Livesey (hamstring) was an unused substitute in that clash and is again available for selection, but it remains to be seen whether or not Peter Murphy, who last featured against the Saints, will recover from a knock in time to feature.
Kevan Hurst (knee), Joe Anyinsah (double hernia) and Andy Cook (foot) remain sidelined.
The Cumbrians were thumped 4-1 at Wembley when the two sides last met as the Saints clinched the Johnstone's Paint Trophy last month.
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