Southend will be without Adam Barrett, Jean-Francois Christophe and Francis Laurent for their bottom of the table clash with Stockport.
All three picked up hamstring injuries in last weekend's 2-2 draw with Oldham and are unlikely to figure again this season.
Boss Steve Tilson is considering handing a full debut to 18-year-old striker Harry Crawford, while Stuart O'Keefe and Jean-Yves M'voto are also set to start.
United remain without long-term absentees Damian Scannell (foot) and Scott Spencer (ankle) while full-back Scott Malone has been recalled by Wolves, bringing to an end his six-month loan spell at the club.
The draw with the Latics sent Southend to relegation and they now have only pride to play for in their remaining two fixtures.
Shrewsbury begin life without manager Paul Simpson.
Simpson, who led the club to the play-off final last season, had his contract terminated with immediate effect having failed to mount a serious challenge for the play-offs this time around.
With the club looking towards the future three loanees, goalkeeper David Button, defender Joe Skarz and striker Jamie Cureton, could miss out to give players closer to home such as Chris Neal and Harry Hooman a chance.
Midfielder Craig Disley (broken ankle), captain Graham Coughlan (thigh) and striker Jake Robinson (ligament damage) are back in training but will probably not figure again this term.
Striker Nathan Elder (knee) also remains sidelined.
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