It's been a massive blow for both the team and Ryan, who was recalled to the team for the play-off matches last season. Taylor must be cursing his bad luck, which seems to have followed him throughout his early career.
Ryan was just starting to show his potential when he was hit by glandular fever during the 2006-07 season, putting the 18-year-old striker's career on hold.
His career since then has been stop-start but he finally seemed to find some consistency at the end of last season with some strong performances on loan at Exeter City and then coming back to Rotherham in time for the play-offs, impressing with three good performances and two goals in the play-off final.
The stage was seemingly set for Ryan Taylor to showcase his talents this season but a fractured fifth metatarsal has once again set him back.
Fellow striker, Tom Pope continues to be sidelined with a metatarsal injury of his own. Pope picked up the injury in April but he's not set to compete for a place in the team until October.
Ronnie Moore has signed Tom Elliott on loan from Leeds United to help fill the void left by Pope and Taylor, but Elliott has also picked up an injury in pre-season training.
He tore a muscle in his leg, and has missed the last two pre-season matches, but he remains hopeful of playing against Tamworth on Saturday.
Injury problems have also hit the defence hard, as right-back Dale Tonge also remains sidelined with a metatarsal injury. Dale struggled with a foot injury from last November onwards and isn't likely to feature in the first team for a month or two.
Fellow right-back, Johnny Mullins has also missed all the public pre-season matches with a calf injury, which has meant that the Millers have been without a recognised right back during pre-season. Reports from the Alfreton friendly also seem to suggest that centre-back Nick Fenton will be joining his team-mates in the physio's room.
*Disclaimer: The views in this article are that of the writer and may not replicate those of the Professional Footballers' Association.