League Two Shrewsbury produced an astonishing fightback from 3-0 down to beat League One Charlton 4-3 in the first round of the Carling Cup at Greenhous Meadow.
The Addicks had appeared to be cruising as Pawel Abbott's first goals for the club and a strike from Lee Martin put them in control.
But Jake Robinson and a Yado Mambo own goal put the Shrews back in it by half-time, and Daniel O'Donnell and Matt Harrold completed the turnaround.
MK Dons were another side to come from behind as Jabo Ibehre's double saw them beat Dagenham and Redbridge 2-1. Damien McCrory had given the visitors a 13th-minute lead.
Jordan Rhodes grabbed his second goal of the season in the 89th minute as Huddersfield secured a 1-0 win at Carlisle.
Doubles from Simon Heslop and James Constable helped Oxford on the way to a 6-1 hammering of Bristol Rovers at the Kassam Stadium. Jack Midson and Matthew Green grabbed their other goals.
Southampton beat League One rivals Bournemouth 2-0 at St Mary's thanks to a strike from Adam Lallana and Alex Chamberlain's first senior goal. Giles Coke got the only goal as Sheffield Wednesday beat Bury while Ian Goodison's tap-in was enough for Tranmere to win 1-0 at Walsall.
Northampton were 2-0 winners over 10-man Brighton as early goals from teenager Michael Jacobs and Billy McKay sealed the win before Matthew Sparrow saw red in the 36th minute.
League One Colchester were too strong for League Two Hereford as they recorded a 3-0 win at Edgar Street thanks to goals from David Mooney (2) and Ian Henderson. Robbie Simpson and Craig Woodman helped Brentford to a 2-1 win over Cheltenham, Shaun Jeffers getting the goal back for the visitors.
Elsewhere, Peterborough cruised to a 4-1 win over Rotherham, Leyton Orient came from a goal down to beat fellow League One side Swindon 2-1 and John Spicer's strike saw Notts County claim a 1-0 victory at Plymouth.
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