Wayne Rooney is set to return for Manchester United in their Barclays Premier League encounter with West Ham at Old Trafford.
Rooney, who has not scored since March, missed Sunday's draw at Fulham with a virus but has trained all week and is virtually certain to make Sir Alex Ferguson's starting line-up.
Rio Ferdinand and Anderson are both nearing a return to first-team duties after respective knee ligament injuries, although neither will be considered to face Avram Grant's men.
And Ferguson admits selecting his teams is becoming a problem again,
"Everyone is fit, although when you get everyone fit at this club it is a nightmare because you have 24 players all reporting and I can only pick 11," he shrugged.
"It is totally unfair. We should be allowed to pick 16 at least."
Ferdinand is not one of those under consideration to face the Hammers, although the 31-year-old has made startling progress since his manager claimed it would be the end of September before he would be available after the freak training ground injury he suffered in a collision with Emile Heskey on England's first day of World Cup training.
As United do have a Manchester Senior Cup tie against Oldham next Wednesday, an opportunity for Ferdinand to begin his comeback from that knee ligament injury is available.
With matches against Everton, Rangers and Liverpool to follow immediately after the international break, the central defender would be a useful man to have around, as would Anderson, who made a reserve team appearance in midweek after completing his recovery from the cruciate knee ligament injury he suffered in February.
However, in both cases, Ferguson is wary of expecting too much too quickly.
"You need to be aware of knee ligament injuries," he said.
"At the moment everything is OK with Rio and it is the same with Anderson. But he has been out for a long time. You have to monitor his progress a lot more carefully."
West Ham are waiting to discover whether they can include new signing Victor Obinna in their squad.
England internationals Carlton Cole, Robert Green and Kieron Dyer are all set to return after being rested for the Carling Cup win over Oxford.
Manager Avram Grant is hopeful Matthew Upson will also be fit after he suffered a blow to the face in the 3-1 defeat to Bolton, though he also has Tal Ben Haim and Manuel Da Costa pushing for selection at the back.
Midfielder Thomas Hitzlsperger remains out with a thigh injury.
Grant insisted the struggling Hammers cannot afford to enter the clash with any form of apprehension.
"It will not be an easy fixture, especially for us because we are trying to get everything more organised and we are only at the beginning of a process - but I don't think Manchester United will have an easy life tomorrow.
"I see the players in training every day and I'm confident we can do something.
"Manchester United are a good team and they have top players. Not only Wayne Rooney and Javier Hernandez but also Dimitar Berbatov and Paul Scholes, who I think becomes younger every year.
"They are the best players, for the moment, in England.
"But I believe in football anything can happen. In football you need to think like this. I think we showed in the past that anything can happen.
"One thing I don't want is for us to give up before the game, nor in the game."
Copyright (c) PA Sport 2009, All Rights Reserved.
Do YOU want to write for GiveMeSport? Get started today by signing-up and submitting an article HERE: https://www.givemesport.com/writeforgms