Oldham boss Paul Dickov will be without strikers Warren Feeney and Kirk Millar for the home clash with Bristol Rovers.
The frontmen are away on international duty with Northern Ireland and Northern Ireland Under-21s respectively.
Latics skipper Reuben Hazell is a major doubt for the game after he came off with a thigh strain in Tuesday's 1-0 home defeat against Shrewsbury in the Johnstone's Paint Trophy.
Midfielder Ritchie Jones and utility player Jason Jarrett missed Tuesday's match with a hamstring injury and sickness respectively, but are both expected to return against the Pirates.
Dickov's men lie fourth in npower League One after collecting eight points from their opening four matches.
After Tuesday's defeat, Dickov said: "We must pick ourselves up and get back to giving the fans something to shout about."
Bristol Rovers boss Paul Trollope is hoping John Akinde will be fit for the trip.
Akinde signed on loan from neighbours Bristol City last week but was ruled out of the 4-0 defeat at the hands of Southampton with a hip flexor problem.
Striker Darryl Duffy made his last appearance for Rovers before joining Hibernian on loan until the end of the season in the Southampton match.
Goalkeeper Mikkel Andersen will continue between the posts for Rovers after he extended his current loan deal from Reading until January.
The Pirates have not won on the road since March and midfielder Chris Lines believes they will have to be on their mettle to turn this run around against an in-form Oldham side.
He told the Evening Post: "Oldham have made a good start and won a few games already, so it's going to be a tough game and we are going to have to perform."
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