Tranmere boss Les Parry has several injury concerns ahead of the visit of Peterborough.
Midfielder John Welsh was withdrawn at half-time during Tuesday`s Johnstone`s Paint Trophy clash with Accrington with a calf problem and could be out for a number of weeks.
Parry used three loan players and a trio of recent signings against John Coleman`s side while eight injured senior players watched from the sidelines.
The long casualty list includes striker Ian Thomas-Moore, who is set to remain at Prenton Park despite being heavily linked with a move to Rotherham.
Parry said: "The issue of Ian's move is dead now and I think he will be here for the rest of the season."
Coventry defender Jermaine Grandison and Derby midfielder Arnaud Mendy, signed on loan earlier in the week, are set to make their league debuts.
Peterborough could be without defender Gabriel Zakuani.
Zakuani was back on the bench for the 3-0 win at Plymouth last weekend after recovering from a groin injury but could still be called up to travel to Cameroon with the DR Congo squad.
Captain Grant McCann is away with the Northern Ireland squad who play a European Championship qualifier in Slovenia on Friday night but is flying back after the game and will be at Prenton Park. He could play if he does not feature for his country.
Right-back Mark Little is beginning a six-week lay-off after injuring his knee and midfielder Lee Frecklington (knee) and winger Chris Whelpdale (thigh) remain on the sidelines.
Winger Nathaniel Mendez-Laing rounds out the absentees after he picked up a knee injury.
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