Arsene Wenger took charge of his 1000th game as Arsenal manager in 2014.
The Gunners were thrashed 6-0 by Chelsea at Stamford Bridge, with Kieran Gibbs famously being incorrectly sent off by Andre Marriner.
Arsenal were blown away early on as goals from Samuel Eto'o, Andre Schurrle and Eden Hazard put Chelsea 3-0 up in the opening 17 minutes.
The hosts added further goals through an Oscar brace and Mohamed Salah to maintain Jose Mourinho's remarkable record against his nemesis.
New Arsenal boss Unai Emery will be hoping for a very different result on Saturday evening.
They lost 2-0 to Manchester City in the opening game of the 2018/19 Premier League season.
The former PSG manager added five new players over the summer - and it's remarkable how much Arsenal's squad has changed since that 6-0 drubbing in March 2014.
GK - Wojciech Szczesny
The Polish 'keeper spent two years on loan at Roma before Juventus paid Arsenal just £10m to bring him in as Gianluigi Buffon's successor.
RB - Bacary Sagna
He joined Man City on a free transfer at the end of the 2013/14 season and recently signed a contract with MLS club Montreal Impact.
CB - Per Mertesacker
Still only 33, the big German defender retired at the end of the 2017/18 season to become the manager of the Arsenal academy.
CB - Laurent Koscielny
The only surviving member of Arsenal's starting XI. Currently sidelined with an achilles injury suffered towards the end of last season.
LB - Kieran Gibbs
The Arsenal academy graduate was sold to West Brom for £6.75m in 2017 after making 137 Premier League appearances for the Gunners.
CM - Mikel Arteta
After retiring in 2016, the Spaniard immediately joined Manchester City to become Pep Guardiola's assistant manager. He was close to becoming Wenger's successor this summer but Emery pipped him to the job.
CM - Santi Cazorla
Arsenal released the magical midfielder this summer after extensive injury problems. Cazorla, 33, hasn't played a competitive game in almost two years but recently proved his fitness to earn a one-year contract at Villarreal.
CM - Tomas Rosicky
He was also plagued by injury problems in north London and retired in 2017, one year after leaving Arsenal for his boyhood club Sparta Prague.
RW - Alex Oxlade-Chamberlain
The versatile Englishman thrived after joining Liverpool in a £35m transfer last summer. Set to miss all of the 2018/19 season after suffering multiple ligament damage during the Champions League semi-final against Roma.
LW - Lukas Podolski
The German forward currently plies his trade for Japanese side Vissel Kobe.
ST - Olivier Giroud
A fan favourite at the Emirates, Giroud swapped Arsenal for Chelsea in January 2018 and played an important role in France's World Cup win this summer.
SUBS
Thomas Vermaelen
The 32-year-old defender joined Barcelona in 2014 but has only made 25 La Liga appearances in four years at the Camp Nou.
Mathieu Flamini
Currently without a club after leaving Getafe at the end of the 2017/18 season.
Lukasz Fabianski
Moved to Swansea City in 2014 and proved himself as a fine Premier League goalkeeper. West Ham shelled out £7m to sign him this summer.
Yaya Sanogo
The 25-year-old striker joined Toulouse on a permanent deal following unsuccessful loan spells at Crystal Palace, Ajax and Charlton Athletic.
Carl Jenkinson
The 26-year-old defender, who has two years remaining on his contract in north London, has only played one Premier League game for Arsenal since 2014.
Kim Kallstrom
The Swedish midfielder joined the Gunners on a short-term loan deal. He retired from professional football in 2017.
Serge Gnabry
Failed to kick on after impressing as a teenager at Arsenal. Joined Werder Bremen for £5m in 2016 before earning a move to Bayern Munich.