Peter Reid's Plymouth claimed their first home League One win of the season despite being reduced to 10 men in first half stoppage time thanks to Craig Noone's 77th-minute winner.
Plymouth went ahead in the 19th minute after Wednesday midfielder Darren Potter slipped while making a pass in the centre of the field.
The ball ran to Bradley Wright-Phillips who raced forward down the inside left channel and beat two players before teeing up skipper Carl Fletcher on the edge of the box.
Fletcher's right footed angled drive from 20 yards flew in off the far post and out of the reach of Wednesday keeper Nicky Weaver, who had twice denied Wright-Phillips in the opening spell.
The visitors levelled in the 38th minute through midfielder James O'Connor, who powered home a far post header from Tommy Spurr's deep cross from the left.
In first half stoppage time, Argyle were reduced to 10 men when right-back Bondz N'Gala was dismissed for a foul on Wednesday striker Neil Mellor in a one-on-one situation.
Wright-Phillips put Plymouth back in front in the 46th minute, heading home a left wing cross from Noone.
That rocked Wednesday who sent on subs Tommy Miller and Clinton Morrison.
On 75 minutes Miller levelled with a cracking long-range half-volley after the ball sat up perfectly for him to let fly.
That joy was shortlived for Wednesday as Jim Paterson - one of five players recalled by Argyle - beat O'Connor down the left wing and crossed to the far post where Noone headed home.
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