In Sunday's primetime matchup, the New England Patriots visited the Detroit Lions.
Bill Belichick's team were heavy favourites ahead of kickoff, as they'd actually managed to pick up a win in the opening two games of the 2018 season.
The Lions, on the other hand, were 0-2 heading into the clash, after already being beaten by the New York Jets and the San Fransisco 49ers.
So, it's fair to say that nobody would have predicted what actually happened on Sunday night.
A MAJOR UPSET
Rather than blowing Detroit away as many expected, New England actually suffered their second loss of the season, falling 26-10 at Ford Field.
Beating Tom Brady and co. handed head coach Matt Patricia his first win of the year - and the Lions did it in some style.
The hosts put up a field goal in the first quarter and really began to pull away in the second.
Matthew Stafford found Kenny Golladay for the first touchdown of the night, firing a pass to his WR from the six-yard line - and Golladay was able to squeeze the ball home, by a matter of inches.
SECOND HALF SCARE
The hosts took at 13-3 lead into halftime, but all their hard work was almost undone in the third quarter.
Stafford turned the ball over early - and saw a pass picked off by Ja'Whaun Bentley before Brady marched his team downfield to score the first points of the second half, bringing the game to 13-10.
However, that turnover didn't seem to rock the Lions too much and their quarterback redeemed himself 10 minutes later, finding Marvin Jones in the end zone with a deep pass from the 33-yard line.
Darius Slay picked off Brady midway through the fourth before two more field goals confirmed Detroit's win - one that shocked fans around the NFL.
A POOR PATS DISPLAY
In reality, as good as the Lions were, the Patriots themselves were pretty poor throughout. Although, we shouldn't take anything away from the Lions.
So bad were Belichick's team though, is it seemed that they wasted a number of big opportunities to take the upper hand.
In fact, there was one moment that proved just that - as it saw the New England defense call what play Detroit were going to run, moments before they did it.
In the video below, the Pats D can be heard shouting "it's a toss" seconds before Stafford flips the ball off to his running back.
Honestly, that's pretty embarrassing for Patricia's team - and this isn't the first time it's happened in 2018 either. In week 1, the exact same thing happened against the Jets.
Clearly, the Lions need to work on their signals - but interestingly, this week, even though they ran predictable plays, they still ran out winners against the Patriots.