With injured Lionel Messi watching on, Philippe Coutinho, Arturo Vidal and a Luis Suarez hat-trick gave the hosts all three points in the first Clasico of the season.
Vidal has been very outspoken about Real's recent Champions League triumphs, and another Barca man who harbours a dislike for Los Blancos is Gerard Pique.
Given his history, the central defender would've been as happy as anyone to see his beloved Barca beat Madrid in such a convincing manner.
In fact, he re-created a rather iconic moment from a famous Clasico back in 2010 after Vidal scored Barcelona's fifth goal - and he's spoken about it too.
The history behind Pique's gesture
In the 2010-11 campaign, Pep Guardiola's Barca celebrated the club's 111th anniversary by beating Real Madrid 5-0 at the Nou Camp.
Following the fifth goal in that game, Pique produced a "five" hand gesture (in reference to each of the goals), and it lives long in the memory of their supporters.
As Sid Lowe once wrote for The Guardian: "Eric Abidal raised his hand. Gerard Piqué raised his. Soon, the rest of Nou Camp joined in - palms open, fingers outstretched.
"It was not that they thrashed Madrid 5-0, defeated (Jose) Mourinho and his unbeaten €292m team. It was that they did it their way (style)."
Pique re-creates "five" gesture in latest Clasico
Only Pique, Sergio Busquets and Messi remain from that team, and the former was at it again on Sunday by bringing back the infamous hand signal - as shown below.
Even Barcelona's official Twitter account couldn't help but reference it:
Pique speaks after Clasico win
The 31-year-old, who endured a sticky patch of form a few weeks ago, was as assured as ever on the ball and defended pretty well when one-on-one with Real's forwards.
After the 5-1 win, in which he made his 460th appearance for Barca, Pique explained his latest hand celebration: "My hand gesture? The situation is simple, we have put (scored) five goals.
"It is a moment to enjoy. I knew I'd go back to my level (top form), it's a matter of time. In the end, criticism is a motivation to be at your level. I've found myself well."
Pique will hope Ernesto Valverde's men can continue to perform at this level when they face Cultural Leonesa, Rayo Vallecano and Inter Milan in three different competitions.
What are YOUR thoughts on Pique bringing back the famous "five" hand gesture after Barca 5-1 Real? Leave YOUR opinion in the comments box below!