Jose Mourinho's Blues side had won the previous two Premier League titles and Sir Alex Ferguson was desperate to get back on top.
It was a tense title race, but the Red Devils managed to seal their ninth Premier League crown and their 16th English title.
United finished six points ahead of Chelsea on 89 at the end of the season, sealing their title win against bitter rivals Manchester City at Old Trafford on May 5.
A Cristiano Ronaldo penalty earned them a priceless 1-0 win and it meant that Ferguson's side didn't have to try and take points from Chelsea the following week.
It also meant that the Blues would be giving their title rivals a 'guard of honour' at Stamford Bridge in the penultimate game of the season.
Both sides had one eye on the FA Cup final, but the team Ferguson fielded that night was just brilliant.
The team was as follows: Tomasz Kuszczak, Kieran Lee, Wes Brown, John O'Shea, Gabriel Heinze (C), Chris Eagles, Alan Smith, Darren Fletcher, Kieran Richardson, Ole Gunnar Solskjaer & Dong Fangzhou.
What an iconic lineup and Ferguson still managed to earn a 0-0 draw.
The likes of John Terry, Claude Makelele and Michael Essien all featured from the start for Chelsea.
Whether it was mind games from Ferguson before the FA Cup final is hard to say.
However, if that was his intention it certainly didn't work, with Chelsea beating United 1-0 in extra-time at Wembley.
Fangzhou's inclusion that day was his only Premier League appearance before leaving United for Dalian Shide in 2008.
As for Lee, the game against Chelsea was also his only appearance in the Premier League for United, before a move to Oldham Athletic in the summer of 2008.
He's now at Sheffield Wednesday.
So there you have it, possibly the most bizarre team to have ever been handed a 'guard of honour'.