We are almost halfway through the season already as game week 16 approaches, the league table is starting to take shape and fans will no doubt be hastily flicking through stat packs in order to pick the best possible eleven for this weekend.
Chelsea and Manchester City have the unfortunate task of facing each other on Saturday which could put some rather big names in the 'ones to avoid'.
Arsenal will be hoping to put their frustrating 2-2 draw with Manchester United behind them as they take on Huddersfield at the Emirates.
United are in a similar boat, desperate to pick up points - Jose Mourinho's side host Claudio Ranieri's Fulham.
Elsewhere, Liverpool host Bournemouth and Tottenham travel to Leicester in what is set to be a long weekend of mouthwatering clashes.
Here are your top tips for the games ahead: Five to pick, five to avoid and those dreaded injuries and suspensions that can ruin your points tally.
Minor Injury Doubts
Sergio Aguero (Manchester City) - Muscle injury
Andrew Robertson (Liverpool) - Dead Leg
Sadio Mane (Liverpool) - Foot injury
Kieran Trippier (Tottenham Hotspur) - Groin injury
Anthony Martial (Manchester United) - Hamstring injury
Glenn Murray (Brighton & Hove Albion) - Shoulder injury
Jamie Vardy (Leicester City) - Muscle injury
Mesut Ozil (Arsenal) - Back injury
Luke Shaw (Manchester United) - Knock
Injuries & Suspensions
Marko Arnautovic (West Ham United) - Hamstring injury (Expected back: 12th Jan 2019)
Harry Maguire (Leicester City) - Knee injury (Expected back: 8th Dec)
Bernard Mendy (Manchester City) - Knee injury (Expected back: 2nd Feb 2019)
Shane Duffy (Brighton & Hove Albion) - Suspended (Date of return: 26th Dec)
Joe Gomez (Liverpool) - Leg injury (Expected back: 19th Jan 2019)
Kevin De Bruyne (Manchester City) - Knee injury (Expected back: 8th Dec)
Davinson Sanchez (Tottenham Hotspur) - Hamstring injury (Expected back: 29 Dec)
Alexis Sanchez (Manchester United) - Hamstring injury (Expected back: 13th Jan 2019)
Rob Holding (Arsenal) - Anterior Cruciate Ligament injury (Expected back: September 2019)
FIVE PLAYERS TO PICK FOR GAME WEEK 16
PIERRE-EMERICK AUBAMEYANG (ARSENAL)
Despite missing a gilt-edged chance against United, Aubameyang is still the top scorer in the league with 10.
The Gabonese striker has over double the number of points (93) for Arsenal than second-placed Hector Bellerin (42) and will likely stop the recent resurgence of a Huddersfield side that has only scored the same amount as the ex-Dortmund striker alone.
MATT DOHERTY (WOLVERHAMPTON WANDERERS)
Doherty gets the honour and the privilege of being included in both this and game week 14's list, but for very different reasons.
The Wolves defender has bagged a goal and an assist in his last two games and is now the most picked player for the Wolverhampton side with 18.7% of you selecting him.
The chance of a clean sheet is likely as Wolves travel to Newcastle, who were trounced 3-0 by West Ham at home just last weekend.
FLORIN ANDONE (BRIGHTON & HOVE ALBION)
With Glenn Murray nursing a shoulder injury, Andone has stepped up in the last two games scoring in each game and earning 16 points in the process.
The Romanian's screamer against Crystal Palace only got the attention of 0.2% of Fantasy users, meaning a good performance from the striker against Burnley could get you some points that others have missed.
ANDER HERRERA (MANCHESTER UNITED)
Herrera has only accumulated 23 points this season which would explain why only 0.2% have picked him, however 17 of these points were picked up in United's last two games.
The Red Devils' back-to-back 2-2 draws with Southampton and Arsenal saw Herrera bag his first goal and assist of the season.
This alone means he is highly likely to start his third game in a row against Fulham and therefore has a chance to continue his good run of form.
HARRY KANE (TOTTENHAM HOTSPUR)
It seems almost too obvious to include him, but for Kane (28.5%) to be outside of the top ten for most picked is rather surprising.
The England captain has scored four in his last five games and if we are being brutally honest, he has yet to hit anywhere near his top form.
Even so, Kane is still second on the goals scored list with nine and could add to his tally away at Leicester this weekend.
FIVE PLAYERS TO AVOID IN GAME WEEK 16
JONAS LOSSL (HUDDERSFIELD TOWN)
The Huddersfield goalkeeper has had a solid season thus far, picking up clean sheets in game week 11 and 13 against Wolves and Fulham respectively.
But a trip to Arsenal is likely to be a bridge too far for the Dane, Lossl is currently 18th in points scored for goalkeepers. Don't expect this too improve this weekend.
MARCUS ALONSO (CHELSEA)
Yes, your eyes are not deceiving you, the player with the highest selection percentage (46.8%), most points scored for a defender (93) and joint second highest for assists (7), Marcus Alonso, is in the one's to avoid list.
Alonso is usually a sure pick for his attacking qualities as a fullback, but the Spaniard is likely to be starved of space against Manchester City, making it very difficult to provide any meaningful impact.
EDEN HAZARD (CHELSEA)
The big guns from Chelsea keep on coming. Even Eden Hazard is likely to struggle at the weekend against Manchester City.
The Belgian is second on the total points list (94) but has only mustered two assists and no goals in his last six games. This is poor for someone of Eden's quality.
Chelsea fans will be hoping I am wrong, but if City play at their fluent best it's hard to see Hazard getting many opportunites to penetrate Guardiola's backline.
RYAN FRASER (BOURNEMOUTH)
Fraser has had an unbelievable season so far, bagging seven assists (2nd overall) and notching 86 points (7th overall).
A visit from Jurgen Klopp's Liverpool could see the Scotsman thrive in a big game but on the contrary, could nullify any threat the 24-year-old has shown up to now.
His 12 points against Huddersfield last week will be extremely hard to replicate against the likes of Virgil Van Dijk.
WILFRIED ZAHA (CRYSTAL PALACE)
Zaha hasn't quite hit the heights of last season despite remaining one of Palace's main threats this season.
The Ivorian has only managed 3 assists in his last ten games, not hitting the back of the net since mid-September.
Zaha stands a lowly seventh in terms of points scored for Palace (46) and despite Palace having every chance of getting a result at the London Stadium, do not expect a telling impact from the Palace winger.