The Champions League group stages are over meaning that the joys of the domestic season are back for another week.
The big clash of this weekend features two old rivals, Manchester United and Liverpool, after both qualified for Europe mid-week, despite United's labouring 2-1 defeat to Valencia.
Tottenham come up against Burnley after fighting to a 1-1 draw at the Nou Camp.
Elsewhere, Arsenal and Chelsea both comfortably topped their respective Europa League groups.
Back to this week though and our five players to pick for this week and the five players we think you should avoid.
But first, for those all-important injuries and suspensions that can cause a needless slip up if left in your side.
Minor Injury Doubts
Callum Wilson (Bournemouth) - Hamstring injury
Sergio Aguero (Manchester City) - Muscle injury
Trent Alexander-Arnold (Liverpool) - Foot injury
Kieran Trippier (Tottenham Hotspur) - Groin injury
Anthony Martial (Manchester United) - Hamstring injury
Jamie Vardy (Leicester City) - Muscle injury
Ben Chilwell (Leicester City) - Knee injury
Mesut Ozil (Arsenal) - Back injury
Luke Shaw (Manchester United) - Knock
Injuries & Suspensions
Marko Arnautovic (West Ham United) - Hamstring injury (Expected back: 12th Jan 2019)
Bernard Mendy (Manchester City) - Knee injury (Expected back: 2nd Feb 2019)
Shane Duffy (Brighton & Hove Albion) - Suspended (Date of return: 26th Dec)
Shkodran Mustafi (Arsenal) - Suspended (Date of return: 22nd Dec)
Wilfried Zaha (Crystal Palace) - Suspended (Date of return: 22nd Dec)
Joe Gomez (Liverpool) - Leg injury (Expected back: 19th Jan 2019)
David Silva (Manchester City) - Muscle injury (Expected back: 3rd Jan 2019)
Kevin De Bruyne (Manchester City) - Knee injury (Expected back: 15th Dec)
Davinson Sanchez (Tottenham Hotspur) - Hamstring injury (Expected back: 29 Dec)
Alexis Sanchez (Manchester United) - Hamstring injury (Expected back: 13th Jan 2019)
Rob Holding (Arsenal) - Anterior Cruciate Ligament injury (Expected back: September 2019)
Aaron Mooy (Huddersfield Town) - Knee injury (Expected back: 2nd Feb 2019)
FIVE TO PICK IN GAME WEEK 17
LUCAS TORREIRA (ARSENAL)
Torreira has completely rejuvenated an Arsenal side that can once again be seen as legitimate title contenders.
The Uruguayan has added goal-scoring to his game recently, scoring two and also bagging an assist in his last three games accumulating 23 points in the process.
Amazingly only 7.1% of players have picked him, so grab him while he is still a shrewd pick.
HEUNG-MIN SON (TOTTENHAM HOTSPUR)
Fans are starting to acknowledge the quality of Son, with the Korean beginning to share the spotlight with Spurs' big three Eriksen, Alli and Kane.
Son's three goals and three assists have all come - bar one assist - in the last four games, scoring 35 points in that time. This has made him the most transferred Spurs player for this week, so jump on the bandwagon.
FELIPE ANDERSON (WEST HAM UNITED)
Anderson has become West Ham's primary outlet for goals and assists this season after a rather slow start.
The Brazilian is sitting 23rd in the list for pick percentage showing his form is starting to make waves in the fantasy world.
And with West Ham travelling to rock bottom Fulham, expect more heroics and therefore points from the £36 million signing.
DAVID LUIZ (CHELSEA)
Luiz's impact has seemingly gone under the radar for fantasy players, with the Chelsea defender sitting pretty in fifth position for points scored for defenders.
Just 7.6% of people have picked him and yet the 31-year-old has bagged 73 points including an impressive 15 points in Chelsea's 2-0 victory over Manchester City.
A sly choice at this stage.
HUGO LLORIS (TOTTENHAM HOTSPUR)
For a World-Cup-winning goalkeeper, 54 points at this stage is not something to write home about.
But Hugo Lloris' Tottenham are up against Burnley this weekend who can't seem to hit a barn door with a banjo at the moment.
Therefore a clean-sheet and therefore a sizable points tally is highly likely.
FIVE TO AVOID IN GAME WEEK 17
SADIO MANE (LIVERPOOL)
Probably the one out of Liverpool's attackers that is struggling the most - with Roberto Firmino's recent return to form.
Sadio Mane missed a sitter against Napoli in the Champions League mid-week and has failed to score in his last six Premier League games.
And with Mourinho's United expected to sit back and starve Liverpool of any attacking space, the Senegalese will most likely struggle.
PAUL POGBA (MANCHESTER UNITED)
When will he start showing how good he really is?
Pogba continues to disappoint not just United fans but deep down all of the football neutrals that want the Frenchman to put on a show in the Premier League.
He hasn't had a goal or an assist in his last six games and is suffering from a serious lack in confidence. He may be third on United's total points list but don't let that fool you.
GYLFI SIGURDSSON (EVERTON)
Sigurdsson has cooled off in recent weeks for Everton and despite his heroics against Cardiff in game week 13, he has provided very little.
The Icelandic is not only struggling for form but the Toffees are up against Guardiola's Manchester City away from home next, need I say any more than that?
DAVID DE GEA (MANCHESTER UNITED)
The best goalkeeper in the world? It may be the case but David De Gea' statistics this season do not suggest this whatsoever.
The Spaniard has only kept a measly two clean sheets this season, earning 46 points. Admittedly a rather frail United defence has not helped matters.
De Gea is also embarrassingly low on the total points scored list for 'keepers - the Spanish number one is currently 17th.
His initial exploits got Chelsea fans extremely excited but Jorginho has become very quiet for the Blues.
Even at his best this season, Jorginho's style of play does not bode well for a fantasy team with the Brazilian-born-Italian's main strength simply knitting play together in deep areas.
7.6% have him in their side and yet you have to move to page 2 of the 'total score' list for him to even appear.