Sitting atop the Premier League table, the Reds have a big opportunity to maintain their lead and deal yet another blow to Jose Mourinho's struggling squad.
The home side are the huge favourites and are yet to lose in the league this season, so few supporters are giving United a prayer ahead of the clash.
Jurgen Klopp has been wise not to underestimated his opponents, though, noting in his press conference: "We have to be angry on Sunday and we will be.
"We fight for our points, we don’t sort problems for others or whatever; we have our own problems and our own targets and we go for them.
Manchester United vs Liverpool
"They still have De Gea in goal. It’s unbelievable. They have strikers – they can switch between Rashford, Lukaku and others; they have Lingard, they have Martial. They have unbelievable quality.
"We don’t judge the points they have, we judge the quality they have, and we prepare for that."
Not everybody is so wary of United, though, and the Red Devils have been highly criticised in the aftermath of their defeat to Valencia.
Daily Mail's combined XI
This negativity is certainly reflected in the customary combined XIs doing the rounds, with the in-form Liverpool players being favoured across the board.
One of the most eye-catching examples this week has come from the Daily Mail and only two United players have made their team.
Aside from picking so few players, though, they have incorporated form to such an extent that players like Paul Pogba - despite having great ability and potential - just don't make the cut.
It really speaks volumes about the current United-Liverpool divide. Check out their team here:
GK - David de Gea
RB - Trent Alexander-Arnold
CB - Virgil van Dijk
CB - Dejan Lovren
LB - Andrew Robertson
CM - Georginio Wijnaldum
CM - Naby Keita
CM - Jordan Henderson
RW - Mohamed Salah
ST - Roberto Firmino
LW - Anthony Martial
That, for the record, is a massive 9-2 swing for Liverpool.
And based on recent games, there's certainly an argument that United deserve fewer inclusions with Alisson Becker producing a number of game-changing moments recently.
There's certainly a strong argument that De Gea is the best in the world, but his current performances just don't stand up to his Liverpool rival.
As for Martial, despite being in brilliant form himself, no shortage of fans would argue that Mane deserve the nod.
Yet regardless of the minutia, such a dramatic presence of Liverpool players just goes to show how far they've progress ahead of United this season.
The Red Devils have gone from second place and victory over Liverpool, to being tipped for certain defeat and potentially missing out on the Champions League.
How many Man Utd players would make your combined XI? Have your say in the comments section below.