The Reds lead the Premier League by a single point after 16 matches, while their visitors on Sunday find themselves no less than 16 points off the pace.
Such a gulf has rarely existed between Liverpool and United in recent decades, and some would argue the divide is getting wider.
Although Jurgen Klopp took his side to a Champions League final last season, Jose Mourinho’s men finished runners-up in the title race.
Despite being more consistent in that regard than their northern neighbours, the Merseysiders haven’t finished higher than fourth under the German.
However, Mourinho could only manage sixth-place in his first season as United boss - a result he’s more likely to replicate than the one he achieved at the second time of asking.
It’s no secret the Red Devils are still suffering from the departure of Sir Alex Ferguson at the end of the 2012-13 campaign.
But was the Scot’s role in their dominance really so much greater than that of the players he sent onto the pitch?
Well, according to Gary Neville, it certainly seems that way.
Jamie Carragher has revealed the ex-United defender recognised just two colleagues to be among the best in the world throughout his career.
“Gary Neville once told me he felt he only ever played with two genuinely world class players in his Manchester United career,” the Liverpool legend wrote in the Telegraph.
“One was Cristiano Ronaldo. The other was Peter Schmeichel. That is how fundamental he was to United's success.”
Considering Neville played alongside the likes of Rio Ferdinand, Paul Scholes and Wayne Rooney it’s a contentious view indeed.
Rooney, for example, is likely to remain the Red Devils’ leading all-time goalscorer for some time yet.
Similarly, Scholes has often been compared to Frank Lampard and Steven Gerrard as one of the best midfielders to grace the English top-flight.
Ferdinand, too, was a key figure in the six Premier League titles and Champions League crown United won during his 12 years at Old Trafford.
Then again, Neville’s use of the phrase ‘genuinely world-class’ indicates he’s being extremely selective in naming Ronaldo and Schmeichel as the only two who fit the bill.
What do you make of Neville’s comments? Share your opinion by leaving a comment below.