It doesn't get much worse than losing to your arch rivals.
As a result, they find themselves further and further away from the top four, now sitting 11 points adrift.
Sadio Mane opened the scoring on 24 minutes before an Allison error gifted Jesse Lingard an equaliser soon after.
However, super-sub Xherdan Shaqiri bagged a brace in the second half as Liverpool regained top spot.
The Swiss may feel a little lucky though as both strikes found the net via a United player, the first through Ashley Young and then Eric Bailly.
He won’t care though.
However, one man who will is David De Gea.
What David Said
The man between the sticks was left angered following the game as he felt he could have saved both efforts had it not been for the deflections.
That’s according to boss Jose Mourinho.
“David is saying in the dressing room two easy balls for him,” he told Sky Sports.
“And because of the rebounds [deflections] he had no chance.
“If you want to speak about fortunate you speak their second and third goals.”
You’ve got to feel a bit sorry for the lad.
The United boss also spoke about how his side ‘couldn’t cope’ with Liverpool’s intensity in the opening stages of the game:
“Liverpool are a strong team, but it’s hard to concede two goals in the moment we conceded and the way the goals happened.
“Our difficult moment was the first 20 minutes.
“We couldn’t cope with their fantastic intensity and pressing, but then we were quite calm and it was controlled.”
Mourinho then revealed how they felt they could have capitalized on Liverpool’s frustration which saw Dejan Lovren spectacularly smash the ball into the crowd from range.
“They became really frustrated when their centre-backs came forwards and fired shots into the stands – that was the period when it was more in control.
“We felt we could win, even a little bit undeservedly.”
United will be hoping to get back to winning ways when they travel to Cardiff at the weekend as they begin their busy festive schedule.
United fans, where can you see your side finishing at the end of the season? Have your say in the comments below.