Week 22 of the Premier League commences with West Ham taking on neighbours Arsenal in what should be an exciting London derby.
Liverpool will be desperate to rediscover their mojo after losing their opening two games of 2019.
The match of the round sees Spurs take on a rejuvenated Manchester United at home. Manchester United's Ole Gunnar Solskjaer will be chasing his fifth consecutive win since taking over from Jose Mourinho at Old Trafford and the Red Devils are 5/2 to win the match at GIVEMEBET.
The caretaker United coach would love nothing more than to notch a win against Spurs boss Mauricio Pochettino.
The former Southampton manager is the favourite to take over permanently at Old Trafford in the summer.
West Ham vs Arsenal
London Stadium holds no fears for the visitors, as Arsenal are set to take on London rivals West Ham this weekend.
The home side hasn't tasted success against Arsenal at home since November 2006, with the visitors winning eight of the last 11 Premier League fixtures.
The last time these two sides met, Arsenal came out on top with a 3-1 win kickstarting a 22-match unbeaten run for Unai Emery's side.
West Ham have conceded 18 goals at home this season, while Arsenal have struggled defensively away from the Emirates Stadium, leaking 21 goals.
Arsenal forward Pierre-Emerick Aubameyang is the joint top goal scorer in the Premier League this season with 14 goals, and the Gunners talisman should prove to be the difference in what should be an entertaining win for the visitors.
Brighton vs Liverpool
Don't be fooled by Liverpool's poor start to 2019, with the Reds maintaining a four-point lead at the top of the Premier League table.
The trip to Amex Stadium will be the perfect opportunity for Jurgen Klopp's side to find their first win of 2019 after consecutive losses to City and Wolves in the FA Cup.
Liverpool remain the best side in the English Premier League by some distance, conceding only 10 goals in the first 21 weeks of the season.
Mo Salah has had a hand in 20 goals this season, with seven assists and 13 goals.
Liverpool have scored more than 2.5 goals in six of their last seven outings in the Premier League this season and should prove to be too strong for a goal shy Brighton side.
Burnley vs Fulham
Burnley will be looking to continue their resurgence when they take on Fulham at Turf Moore.
Sean Dyche's side have done well over the holiday season with consecutive wins lifting them out of the relegation zone in the Premier League.
A stoppage time winner from Chris Wood helped the Clarets edge out Barnsley in the midweek round of the FA Cup, signalling that the tide may have turned for the home side.
Fulham were shocked by League Two side Oldham in the FA Cup 2-1 and will be needing Aleksandar Mitrovic to rediscover his goalscoring form after a missed penalty against Oldham.
Claudio Ranieri's side are struggling for form and confidence and expect Burnley striker Chris Wood to take advantage of the visitor's leaky defence.
Cardiff vs Huddersfield
The Terriers haven't claimed any points in the Premier League since their 2-0 win over Wolves at the end of November 2018.
Huddersfield were dumped out the third round of the FA Cup, with a midweek 1-0 loss to Bristol City.
Huddersfield are on a nine-game losing run across all competitions and will struggle to remain competitive with the threat of relegation looming.
Cardiff will be chasing their fifth win of the season and will be confident of claiming all three points, winning three of the last four fixtures against the Terriers across all competitions.
Crystal Palace vs Watford
Crystal Palace have emerged from a worrying form slump to record four wins from their last six matches, across all competitions.
The Eagles' 2-0 win over Wolves in Week 21 of the Premier League leaves them six points clear of the relegation zone in 14th place on the table.
Watford have lost only one of their last six Premier League matches and sit two-points adrift of Leicester City, in eighth place.
Crystal Palace have failed to score in seven games at Selhurst Park this season and another low scoring affair is on the cards.
The Hornets have struggled to find the back of the net away from home and have seen fewer than three goals in seven of their last 10 away games in the Premier League.
Leicester vs Southampton
Claude Puel's side will be expected to bounce back from a shock 2-1 defeat to Newport County in the FA Cup.
The Foxes will be confident of returning to form, facing a Southampton side that has only defeated them twice in the last five seasons.
The Saints have lost six of their last nine away trips and face a Leicester side that has won three of their last four matches in the Premier League.
Southampton have struggled to score at King Power Stadium with their goal drought standing at 370 minutes.
The impact of England striker James Vardy can't be underestimated for the home side with Vardy having a hand in five of the last eight goals for Leicester in the Premier League.
Chelsea vs Newcastle
The clash with Newcastle gives Chelsea the perfect opportunity to bounce back from their controversial 1-0 midweek loss to Spurs.
While the Blues will feel aggrieved with the VAR decision in the first leg of the Carabao Cup, Maurizio Sarri will be hoping his side can rediscover their goalscoring form.
Chelsea have been unable to find the back of their net in their last two matches in the Premier League with a 1-0 loss to Leicester followed up with a goalless draw to Southampton.
Newcastle haven't tasted success in their last six matches to Stamford Bridge, conceding 18 goals against the home side.
Eden Hazard will again be the difference between the teams, with the Belgian midfielder scoring 10 goals in the Premier League this season.
Hazard has scored six goals in his last five matches against Newcastle at home and is tipped to continue his stellar run against the Magpies.
Sunday 13 January
Everton vs Bournemouth
Both of these sides have been sliding in the wrong direction after a promising start to the Premier League season.
Everton have lost four of their past five games to drop to 11th place in the Premier League table.
Bournemouth are one spot below Everton after losing nine of their last 11 games across all competitions.
The Cherries have lost their last five consecutive matches away from home and alarmingly conceding three goals in the last three games.
Bournemouth are struggling for confidence and Everton should be able to take full advantage at Goodison Park and claim all three points.
Spurs vs Man Utd
Interim Manchester United coach Ole Gunnar Solskjaer faces the first real test of his reign with an away trip against Spurs.
Solskjaer will be chasing his fifth consecutive win since taking over from Jose Mourinho in December.
United have been transformed under Solskjaer, but the Reds' four previous wins have come against sides in the bottom half of the Premier League table.
Spurs outclassed United 3-0 at Old Trafford earlier in the season and have won seven of their last eight matches across all competitions.
United will have to find an answer to Harry Kane without Eric Bailly, Chris Smalling and Marcos Rojo.
The England captain has 19 goals for the season across all competitions and will provide Ole Gunnar Solskjaer with plenty of headaches.
A win for Spurs will give them their first league double over Manchester United since 1989/90 Premier League season.
Monday 14 January
Man City vs Wolves
Pep Guardiola's side warmed up for their clash with Wolves with a 9-0 drubbing of Burton Albion in the midweek Carabao Cup clash and sit four points adrift of Liverpool at the top of the Premier League table.
City can ill-afford to drop points in the second half of the season and will be expected to continue their attacking approach against Wolves.
The visitor's record against City is a concern, winning one of their last 10 matches against City across all competitions.
Wolves have struggled to find the back of the net away from home with only 11 goals in the Premier League this season.
City look to be back to their best and while both of these sides have beaten Liverpool in 2019, expect City to record a comfortable win to nil.News Now - Sport News