Nothing scuppers your average fantasy team like an injury to Harry Kane.
Tottenham's faint title hopes have been dealt a hefty blow with the announcement that the Premier League's joint top-scorer is out until March, but their top four rivals will be rubbing their hands at the news.
Liverpool are be looking to extend their four-point lead at the top when they take on Crystal Palace, knowing Manchester City will be ready to pounce against Huddersfield should they slip up.
Likewise, Chelsea can't afford to give Manchester United or Arsenal any hope of closing a six-point gap on the top four.
The Ole Gunnar Solskjaer revolution has seen the Red Devils surge back into the reckoning. They take on Brighton at home this weekend.
GiveMeSport takes a look at the top tips for gameweek 23, including the injuries and suspensions to watch out for.
Don't forget the Asian Cup too, which rules out the likes of Brighton's Mat Ryan (Australia) and Tottenham's Son Heung-min (South Korea).
Minor Injury Doubts
Joe Gomez - returning from leg break
Callum Wilson - hamstring
Phil Jagielka - knock
Gini Wijnaldum - knee
Injuries & Suspensions
Harry Kane - ankle ligaments (Expected back: March 2019)
Marouane Fellaini - calf (Expected back: Feb2019)
Moussa Sissoko - groin (Expected back: 2nd Feb 2019)
Trent Alexander-Arnold - knee ligaments (Expected back: 16th Feb 2019)
Benjamin Mendy - knee (Expected back: 2nd Feb 2019)
Henrikh Mkhitaryan - metatarsal (Expected back: 3rd Feb 2019)
Lewis Cook - ACL (Expected back: June 2019)
Danny Welbeck - broken ankle (Expected back: unknown)
Rob Holding - ACL (Expected back: June 2019)
Simon Francis - ACL (Expected back: June 2019)
Robbie Brady - suspended
Aaron Lennon - knee (Expected back: unknown)
FIVE PLAYERS TO PICK FOR GAME WEEK 23
Gabriel Jesus (Manchester City)
Despite a low start to the season, the Brazilian has scored seven goals in his last three games and will be confident of boosting that tally even further against managerless Huddersfield.
When the two sides met back in August, City put six past the relegation candidates and it took Jesus just half an hour to get on the scoresheet.
Dele Alli (Tottenham Hotspur)
In the absence of Kane and Son, Spurs need their attacking midfielders to step up. Fortunately, they head to Fulham on Sunday knowing Claudio Ranieri's side officially have the worst defence in the league, conceding 49 in 22 games so far.
While he missed some decent chances in the defeat to United, Alli has a respectable tally of six goals and two assists in all competitions this term.
It's possible that Mauricio Pochettino will employ him as a false nine with the Lilywhites so short up front.
Andy Robertson (Liverpool)
Robertson has been rewarded with a new contract and it's no less than he deserves.
The Scottish international may well be on course for a clean sheet, as Liverpool welcome Crystal Palace, whose struggle for goals this season has been well-documented.
Mo Salah, with seven, is the only Liverpool player to have provided more assists than the left-back over the course of the campaign.
Marcus Rashford (Manchester United)
Fresh off the back of scoring the winner at Wembley, Rashford has been one of the most obvious beneficiaries of Solskjaer's arrival.
United's home fixture against Brighton looks much more like a sure banker than it would have done under Jose Mourinho.
Crucially, in the interim manager's five league games in charge, Rashford has scored in four of them.
Gylfi Sigurdsson (Everton)
Everton face a potential banana skin away to Southampton but their hopes will rest on their Icelandic talisman.
The 29-year-old is joint-top of the Toffees' goalscoring charts alongside Richarlison, having found the back of the net nine times and assisted another three.