Young Boys staged a late comeback to book their place in the last 32 of the Europa League with a 4-2 win at home to Group H leaders Stuttgart.
David Degen gave the Swiss side a 35th-minute lead but they fell 2-1 down to goals from Pavel Pogrebnyak (48) and substitute Sven Schipplock (68).
Scott Sutter drew the Bern club level 10 minutes later before a quickfire brace from Emmanuel Mayuka inside the final 10 minutes earned Young Boys the points.
Their 3-0 defeat away to Stuttgart earlier in the tournament means they cannot take top spot but they are guaranteed second after Odense of Denmark and Spanish side Getafe drew 1-1 to leave them both five adrift of Young Boys.
Metalist Kharkiv booked their place in the last 32 as well, as Denis Oliynyk's goal three minutes from time gave them a 2-1 home win over Debrecen of Hungary. The Ukrainians fell behind to Peter Czvitkovics' goal early in the second half but an Adam Bodi own goal pulled Metalist level.
Oliynyk's late winner ensured Metalist of at least second place in Group I as they are now five points ahead of Sampdoria, who lost 2-1 to group leaders PSV Eindhoven at the Stadio Luigi Ferraris. Giampaolo Pazzini gave the Genoa side the lead on the stroke of half-time but the Dutch team fought back and an Ola Toivonen brace earned PSV all three points.
AEK Athens are in pole position to qualify alongside Zenit St Petersburg from Group G after the Greek side won 3-1 away to Hajduk Split of Croatia.
A penalty from Nacho Scocco put AEK in front five minutes into the second half and they added further goals through Kostantinos Manolas (61) and Ismael Blanco (84) to make the game safe before Jurica Buljat's last-minute consolation for the hosts.
New Russian champions Zenit were already assured of top spot in Group G prior to their 3-1 win over Anderlecht.
Aleksei Ionov got Luciano Spalletti's men off to the perfect start with a 12th-minute goal and Alexander Bukharov added a 65th-minute second. Impressive substitute Ziguy Badibanga set up Kanu to pull one back for Anderlecht but Szabolcs Huszti restored the two-goal cushion in the 88th minute to extend Zenit's 100% record in the group to five games.
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