Paris Saint-Germain face Manchester United in one of the most mouth-watering ties to emerge from the Champions League Round of 16 draw.

When it was announced back in December, Paris were firm favourites but United's run of ten wins in 11 games under interim boss Ole Gunnar Solskjaer means things are different now.

An Edinson Cavani penalty gave PSG a 1-0 win over Bordeaux on Saturday, stretching their lead at the top of Ligue 1 to 13 points, but the match didn't come without consequences.

Cavani and Thomas Meunier were both forced off with thigh and head injuries respectively, while Marco Verratti was withdrawn 59 minutes into his first-team return.

So, with some big names listed as major doubts, as well as main man Neymar already ruled out, how could Paris line-up against Man Utd at Old Trafford on Tuesday?

Which PSG stars are definitely out?

Neymar, who's recorded 20 goals and 11 assists in just 23 games this season, suffered a foot injury on January 23 and faces a lengthy spell on the sidelines.

Earlier this week, the world-class Brazilian was spotted on crutches in Barcelona as he underwent stem cell and platelet-rich plasma treatment.

Adrien Rabiot has become the forgotten man in the French capital but let's not forget that he made a whopping 50 appearances in 2017-18 as Paris regained the league title.

However, the 23-year-old's refusal to renew his contract has led to him being ostracised by manager Thomas Tuchel and he's now training with the reserves.

Which PSG players are major doubts?

Meunier and Cavani are both doubtful to recover in time for Paris' trip to Manchester and, despite his return, Verratti is also another question mark.

The Italian maestro only lasted for 19 minutes in PSG's 9-0 destruction of Guingamp last month before coming off injured, and Saturday marked his first outing since.

After Paris 1-0 Bordeaux, Tuchel said: "Without Neymar, without Marco Verratti, and now without Edinson Cavani, we are no longer looking at Plan B, but Plan D."

How Paris could line-up at Man United

Those who have followed Paris' 2018-19 campaign under Tuchel will know the ex-Borussia Dortmund manager has used three systems: 3-4-3, 4-2-3-1 and 4-3-3.

Given that Gianluigi Buffon played against Bordeaux, it's likely that World Cup winner Alphonse Areola will return in between the sticks for the French champions.

Juan Bernat and Layvin Kurzawa will compete for the left-back spot, and Tuchel may have little choice but to continue fielding defenders Marquinhos and Dani Alves in central midfield.

Cavani's thigh injury coupled with Neymar's absence means Eric Maxim Choupo-Moting, relegated with Stoke City last season, is set to join the dangerous Kylian Mbappe in attack.

Predicting PSG's starting XI

3-4-3: Areola, Marquinhos Silva Kimpembe, Kehrer/Diaby Paredes Draxler Bernat/Kurzawa, Mbappe Choupo-Moting Di Maria

4-3-3: Areola, Kehrer Silva Kimpembe Bernat/Kurzawa, Alves/Nkunku Marquinhos Draxler, Mbappe Choupo-Moting Di Maria

4-2-3-1: Areola, Kehrer Silva Kimpembe Bernat/Kurzawa, Marquinhos Paredes/Alves, Mbappe Draxler Di Maria, Choupo-Moting

Paris are still more than capable of beating Man Utd, but their injury crisis is a stark contrast to the Red Devils, who rested Victor Lindelof, Jesse Lingard and Marcus Rashford at Fulham.

Chris Smalling returned after a two-month absence and United will fancy their chances of causing PSG big problems with Paul Pogba, Anthony Martial and Rashford.

What do YOU think Paris' starting XI will be in the first-leg against Man Utd? Do YOU think Man Utd can topple the French champions over two legs? Leave all YOUR opinions in the comments box below!