Plymouth manager Peter Reid will be boosted by the return of first-choice keeper David Button, captain Carl Fletcher and versatile left-sided player Jim Paterson for the visit of Exeter.
Button has missed 16 games in all competitions and nearly three months of action after suffering an ankle injury during the 1-1 draw with Colchester, but is available for selection again.
Fletcher has been suffering from a leg injury and has missed the last eight games, while Jim Paterson has been in training for a couple of weeks now since returning from a troublesome hamstring.
Midfielder Luke Summerfield could be out for a further three months after damaging medial knee ligaments in training, having not yet resumed full training following a twisted knee.
Other than Summerfield, Reid has no other injury or suspension problems to worry about.
Exeter striker John O'Flynn is pushing for a place in manager Paul Tisdale's starting line-up.
The four-goal hitman, who has been struggling with a groin injury recently, had been in line for a return to action against Tranmere last week, but freezing weather conditions saw the game postponed.
However, having another week's training will have only boosted the Irishman's chances of a start, and his return means Tisdale has plenty of attacking options.
Daniel Nardiello's injury-time equaliser as a substitute last time out at Oldham will also have boosted his own chances of a recall.
The enforced break has also given defender Richard Duffy a better chance of shaking off a slight hamstring injury.
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