Not only can the Red Devils move a step closer in ensuring a top four finish but they could also pull the title closer to their Manchester counterparts.
Table-toppers Manchester City turn their attentions to Carabao Cup glory this weekend meaning Liverpool could regain top spot in their league absence.
But United will have their sights firmly on victory.
Especially interim manager Ole Gunnar Solskjaer who will be looking to get one over his Liverpool-supporting friends back in Norway, according to the Manchester Evening News.
And the 45-year-old didn’t hold back, implying that their title hopes fade out when October comes around, saying: “I have loads of Liverpool fans back home and it has been like every year is going to be their year. It has got to October and it's 'OK, next year'."
It’s a drought that has stemmed back to 29 years with memories having to be cast back to 1990 to recall the last time Liverpool had their hands on the top-flight title.
In the meantime though, United have been crowned champions of England on 12 occasions, exceeding the Reds’ record of 18 league titles.
However, a 19th remains very much in Liverpool’s sights this time around but Solskjaer went on to say that it is no concern to United: "Now they are in the race so now for them it is going to be an exciting finish to the league now they are in it.
"That is none of our concern. We just have to concentrate on ourselves."
Solskjaer will be in high spirits going into this afternoon’s game as the Norwegian is yet to taste defeat in the league since taking the reins at Old Trafford.News Now - Sport News