Jarrell Miller has failed his second drugs test in the space of a week, according to ESPN.
Sources informed Don Rafael that the American boxer had tested positive for HGH (human-growth-hormone) during a routine VADA test in March.
His positive test for the banned substance GW1516 had already placed his scheduled bout with Anthony Joshua on June 1 in serious doubt.
However, any chance of Miller being reprieved seem to have disappeared after his latest failure to meet the anti-doping rules within the sport.
It's been confirmed that the test result that found HGH came from a different sample to the one collected on March 20, which caused the initial controversy.
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Miller denies intentionally doping
Promoter Eddie Hearn is in the process of finding a new opponent for Joshua with the likes of Luis Ortiz, Kubrat Pulev and Adam Kownacki stepping into the ring.
"I am absolutely devastated upon hearing the news my boxing licence has been revoked in NY State and I will be vigorously appealing this decision," Miller wrote on Instagram.
"I have NEVER knowingly taken any banned substance and when I found out the news last night I was totally shocked.
What's the future for Miller?
"My team and I stand for integrity, decency & honesty and together we will stand to fight this with everything we have!
"This was a voluntary test that I was very happy to do and these results came just one week after another voluntary test that I had taken which was completely clean.
"I refuse to just lie down and let my dream be taken away from me when I know in my heart that I've done nothing wrong.
"Fifteen years of hard work. I'm a WARRIOR .. I don't need a banned substance.
"Remember, don't believe everything you hear and see. The facts will prevail and I shall be vindicated. I don't have anything to hide and the truth will make itself known."
The decision surrounding Miller's future currently revolves around the 'B Sample', although a second failed test seems to end any hopes of him fighting Joshua.
VADA are an independent company and Joshua's team piles massive fundings into ensuring all his opponents are rigorously tested in the run-up to fights.
It will be up to the New York commission to decide on Miller's punishment and with two adverse findings to his name, it could spell a lengthly ban for 'Big Baby.'
One thing it certainly doesn't solve, though, is Hearn's headache about sorting a new opponent and it seems the number of options are dwindling by the day.
Who should Joshua fight on June 1? Have your say in the comments section below.News Now - Sport News