Tranmere will assess the fitness of Gunnar Nielsen ahead of the visit of Carlisle.
The on-loan Manchester City goalkeeper missed Saturday's defeat at Rochdale due to illness and will be looked at ahead of Monday's encounter.
The 24-year-old could have played his last game for Rovers with his loan set to come to an end on Tuesday, with Joe Collister in line to deputise.
Liam Darville, borrowed from Leeds, has a head injury and is unlikely to play as he prepares to return to Elland Road following the Carlisle match.
Manager Les Parry is undecided on the futures of fellow loanees Jermaine Grandison and Scott Wootton, although they are both set to feature.
Defender Marlon Broomes starts a three-game ban following his dismissal in the loss at Spotland.
Carlisle could include new signing Marc-Antoine Gbarssin in their squad.
The 26-year-old French midfielder signed a one-month contract on New Year's Day after a recent trial and could be handed a longer-term deal.
The Cumbrians are expected to be without injured striker Ben Marshall, on loan from Stoke, who was forced off in the first half during the 2-2 draw with Huddersfield and was replaced by skipper Paul Thirlwell.
Thirlwell is likely to return to the starting line-up if Marshall misses out, but otherwise manager Greg Abbott has no other new injury problems.
Abbott must decide whether to recall striker Francois Zoko, who headed a late equaliser against Huddersfield, or retain on-loan Leeds forward Mike Grella.
Defenders Sean McDaid, Tony Kane (both knee) and Danny Livesey (groin) remain sidelined.
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