Matchweek four of the Premier League kicks off on Saturday afternoon and this weekend brings the first big derby of the season, as well as a few other subplots to keep an eye on.
Arsenal and Tottenham will battle for north London's bragging rights, while Liverpool look to continue their perfect start to the campaign away to Burnley.
There's also a chance for Manchester City's Raheem Sterling to break August's goalscoring record - his side face Brighton at home tomorrow.
Ahead of another exciting weekend of football, here's our preview of the action, with some of the best tips from GIVEMEBET along the way.
Southampton vs Manchester Utd
Southampton picked up their first win of the season against Brighton last weekend, but they have another tough test against of the league's biggest teams this week, just 14 days after losing 2-1 to Liverpool.
Man United aren't exactly on fire though, after suffering a shock defeat at home to Crystal Palace last week. Ole Gunnar Solskjaer's men will be hoping to bounce back with a win.
(GMB odds - Man United to win & BTTS)
Chelsea vs Sheffield United
Frank Lampard picked up his first win as Chelsea manager against Norwich in week three, and a home tie against newly-promoted Sheffield United should see the Blues take another three points.
Like Southampton, the Blades also have one win from three, but it will be a tough ask to get anything from their trip to Stamford Bridge.
Crystal Palace vs Aston Villa
After a brilliant win at Old Trafford, Crystal Palace will hope to make it two in a row against Aston Villa. However, they did lose to Colchester in the Carabao Cup on Tuesday.
And now that Villa have picked up their first Premier League win since 2016, we could see Dean Smith and his players celebrating at full-time instead.
Leicester vs Bournemouth
Leicester currently sit fourth in the table after a win and two draws from their opening fixtures and they host Bournemouth with the hope of staying unbeaten.
But after being beaten 3-1 by Man City last weekend, the Cherries will want to pick up a much needed three points themselves.
Man City vs Brighton
Pep Guardiola's City need another win to keep the pressure on Liverpool and they will be confident of beating Brighton at the Etihad.
Graham Potter's side lost to Southampton last weekend and it's likely they will fall into the bottom half of the table with another defeat.
(GMB odds - Man City to score over 3.5 goals)
Newcastle vs Watford
Newcastle stunned Spurs with a 1-0 win in north London last weekend, but even those points weren't enough to take them out of the relegation zone after three games. Another win against Watford certainly would though.
The visitors themselves are in desperate need of a win, as they currently sit rock bottom of the table with zero points.
(GMB odds - BTTS)
West Ham vs Norwich
West Ham were the side that inflicted Watford's latest league defeat last weekend and now Manuel Pellegrini will want to see his team pick up three more points against Norwich.
But the Canaries won't be a pushover. They impressed once again at home to Chelsea last week but narrowly lost 3-2. Teemu Pukki already has five goals to his name and could bag again on Saturday.
(GMB odds - West Ham to win & BTTS)
Burnley vs Liverpool
Burnley will be hoping to bounce back from a shock midweek defeat to Sunderland in the Carabao Cup, but face the Premier League's top team in Saturday's late kick-off.
Liverpool are the only side left with a 100% record and Jurgen Klopp will expect to make it 12 points from 12 after four fixtures.
(GMB odds - Liverpool to win & BTTS)
Everton vs Wolves
Everton and their big summer signings are yet to really click, with one win, one draw and one defeat from their first three matches.
Marco Silva will be hoping for a much-needed win but Wolves, who have drawn all of their games so far, will be just as desperate to finally taste victory.
(GMB odds - BTTS)
Arsenal vs Tottenham
This is the big one. It's not just bragging rights on the line in the north London derby, because this game will have a big effect on the race for a Champions League spot.
Arsenal will be made slight favourites after starting strongly this season, but derbies are unpredictable and it will all come down to who wants it more.News Now - Sport News