Leading scorer Clayton Donaldson is suspended for Crewe`s home game against Accrington.
The 16-goal striker was sent off for violent conduct during the home win over Bradford on Tuesday night and begins a three-match ban.
With Calvin Zola having joined Burton on loan, Donaldson`s absence opens the door for either Ajay Leitch-Smith or Joel Grant to come into the side.
Both players got a run-out in a reserve-team fixture at Aston Villa this week.
Alex boss Dario Gradi has another selection conundrum as on-loan goalkeeper Rhys Taylor is available again after serving a one-match suspension against Bradford.
Gradi must decide whether to recall the Chelsea youngster or stick with the experienced Steve Phillips, who made his first start of the season against the Bantams.
Accrington manager John Coleman could be boosted by the return of Dean Winnard.
The defender missed the home defeat against Shrewsbury due to illness, but is expected to return after shaking it off during the 10-day period Stanley have been without a game.
Joe Jacobson looks set to continue in defence following Kevin Long's return to parent club Burnley with a broken toe, but Leam Richardson is also in contention for a starting berth as is Jonathan Bateson following his recent reserve-team outing against Preston.
Coleman is hoping to secure the signing of Ian Craney. Craney left the club after his loan from Fleetwood expired, but Stanley are still keen on capturing his signature.
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