After the return of European football, both in the Champions League and the Europa League, it's back to domestic action for the top clubs in England.
It was a mixed week for the Premier League as only Manchester City, Arsenal and Manchester United picked up wins, whilst there were defeats for Chelsea, Liverpool and Wolves.
It's gameweek six this weekend, and there are plenty of mouthwatering ties in store.
FRIDAY
Southampton vs Bournemouth
The weekend of action starts this evening as Southampton host Bournemouth, and it couldn't be any tighter between the two. Both have seven points; winning two, losing two, and drawing one. However, the Saints only scoring five goals in five games is a cause for concern.
(GMB odds - Under 2.5 goals 23/20)
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SATURDAY
Leicester vs Tottenham
What an exciting match this promises to be at the King Power Stadium on Saturday lunchtime. Leicester are the team fancied to break the top-six, and they've started well under Brendan Rodgers. Eight points from five games sees them go into this tie level on points with Mauricio Pochettino's Spurs, who have been far from convincing so far this season.
Burnley vs Norwich
How can the Canaries follow up their impressive win against champions Manchester City? Going on that performance alone, you'd back Daniel Farke's men to win at Turf Moor, but the Premier League is never that easy. A home win would see the Clarets overtake Norwich in the league.
Everton vs Sheffield United
The Phil Jagielka derby. Just the two points separate these two going into the game at Goodison Park, but it's surely deemed a must-win for Marco Silva, given the fact that Everton were also one of the pre-season favourites to break into the top-six.
(GMB odds - Everton to win 2-0 29/4)
Manchester City vs Watford
Pep Guardiola's men bounced back emphatically in the Champions League this week, and they'll be confident they can secure all three points once again here. However, the Hornets produced their performance of the season so far during their 2-2 draw with Arsenal last weekend.
(GMB odds - Man City to win 6-0 23/1)
Newcastle vs Brighton
Too early to call it a six-pointer? Both sides sit uncomfortably close to the drop zone, and it wouldn't be a surprise to see them near there come May. It's a game neither will want to lose, that's for sure.
SUNDAY
West Ham vs Manchester United
A game between two teams you just never know what you're going to get. They both sit on eight points going into the game; winning two, drawing two, and losing one, so it's a tough one to predict. How will Ole Gunnar Solskjaer's men deal with a Thursday-Sunday double header for the first time this season?
(GMB odds - West Ham to win & BTTS 4/1)
Crystal Palace vs Wolves
If you said before the season after five games one would be on seven points and one would be on three, you'd expect Wolves to be the team in front. However, they find themselves 19th and without a league win going into this game with the Eagles, paying for their efforts in Europe it seems.
(GMB odds - Palace to win 33/20)
Arsenal vs Aston Villa
The horror show at Vicarage Road has been forgotten about for now after Unai Emery's men bounced back with a 3-0 win in Germany on Thursday night, and with Aston Villa at home this weekend, they'll be confident they can put things right in the league as well.
(GMB odds - Arsenal to win to zero 17/10)
Chelsea vs Liverpool
Good things come to those who wait, and the final game of the Premier League this weekend is the best. Chelsea will be looking to build from their emphatic 5-2 win over Wolves last weekend, whilst Jurgen Klopp's men will want to remain the only team with a 100% record. Five games and five wins so far for the European champions.