The two famous clubs met twice last season in the group stage and were drawn in the first round against each other again this season.
This time around, Inter arrive with a new boss - Antonio Conte - and a serious air of optimism around the club.
The signings of Romelu Lukaku and Diego Godin appear to be a masterstrokes and Inter are currently unbeaten in Serie A and two points clear of Juventus at the top.
With Barca and Lionel Messi out of form, Inter will fancy their chances in the Camp Nou in what could be another memorable game.
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However, it would take a spectacular meeting between the pair to outdo either of their famous clashes in the 2009/10 Champions League semi-final.
Inter won 3-2 on aggregate to progress to the final and they would go on to lift the treble that season.
The lineups from both teams during their first clash at San Siro - which Inter won 3-1 - will evoke many memories for lovers of the game.
So many legends on show and even warming the bench.
Manager: Pep Guardiola
Starting XI: Victor Valdes, Dani Alves, Gerard Pique, Carles Puyol, Maxwell, Sergio Busquets, Xavi, Seydou Keita, Lionel Messi, Zlatan Ibrahimovic, Pedro
Bench: Pinto, Rafael Marquez, Eric Abidal, Gabriel Milito, Thierry Henry, Bojan, Yaya Toure
INTER MILAN'S TEAM
Manager: Jose Mourinho
Starting XI: Julio Cesar, Maicon, Lucio, Walter Samuel, Javier Zanetti, Thiago Motta, Esteban Cambiasso, Wesley Sneijder, Samuel Eto'o, Diego Milito, Goran Pandev
Bench: Paolo Orlandoni, Ivan Cordoba, Marco Materazzi, Cristian Chivu, Dejan Stankovic, Sully Muntari, Mario Balotelli
The only legendary face missing was Andres Iniesta, who was sadly injured for the entirety of tie.
Sneijder, Maicon and Mililto scored the goals in the first leg to cancel out Pedro's opening strike, but it was the second-leg where the most iconic image of the tie was created.
Motta was shown a straight red early on in the Camp Nou, with Pique scoring in the second-half to give the Blaugrana serious hope.
But Inter miraculously held on, leading to Mourinho charging on to the pitch and celebrating in front of the Barca fans.
What a night, what a tie.News Now - Sport News