Jurgen Klopp's Reds have grown from a raw, talented outfit into arguably the best team in Europe during the last two years, while United have continued to regress.
Ole Gunnar Solskjaer has struggled to reverse the club's slump in the post-Sir Alex Ferguson era and he already faces an uphill battle against Liverpool on Sunday.
The United manager will be without David de Gea and Paul Pogba, while Klopp's side are set to be at full-strength at Old Trafford.
A fearsome prospect for the hosts, but there is one statistic they can take into the game to hand them some hope.
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The only goal from the attacking trident against the Red Devils came last season in Liverpool's 3-1 at Anfield, with Mane opening the scoring.
As for Salah and Firmino, they have never found the back of the net against United.
It's quite an anomaly, given how prolific the trio have been against the rest of the Premier League's top six.
Just this season, Salah has scored twice against Arsenal, while Firmino netted in the 2-1 win away at Chelsea.
Firmino has also scored a hat-trick against the Gunners and also found the back of the net away at Manchester City last season as well.
Even during Salah's record-breaking season - where he scored 32 league goals - United were the only top six side he failed to score against.
It's certainly an interesting narrative heading into Sunday's big game, but the odds will be heavily in the favour of Liverpool's trio to dominate proceedings.
You really wouldn't bet against all three finding the back of the net...News Now - Sport News