New signings Connor Clifford and Kevin McDonald could be in line to make their full debuts for Notts County when Colchester visit Meadow Lane.
The loanees, from Chelsea and Burnley respectively, made their first appearances for the club as second-half substitutes during the home defeat to Exeter on Saturday.
The duo could force their way into the starting line up after assistant boss Alex Rae admitted that Notts `looked better` following their introduction.
No new injuries were incurred at the weekend but changes could be possible, with the likes of John Thompson, Graeme Lee, Lewis Gobern, John Spicer and Ben Burgess joining Clifford and McDonald in the mix for starting roles.
Notts are without a league win since beating Hartlepool 3-0 on January 3.
Colchester manager John Ward could have defender Nathan Clarke back.
The on-loan Huddersfield centre-back missed Saturday's 2-1 home win over Swindon with an ankle injury but he could be available if he comes through a late fitness test.
Goalkeeper Ben Williams made a return on the bench against the Robins after recovering from a back problem and he is likely to occupy that place again as his replacement Mark Cousins has performed well.
Magnus Okuonghae and Brian Wilson will again miss out due to their respective ankle injuries as does fellow defender Morten Knudsen, who signed for the Us last January but has still not made an appearance due to a knee injury, although the trio are closing in on full fitness.
On-loan Icelandic midfielder Matthmas Vilhjalmsson and fellow January signing Conor Powell are pushing for places in the squad although they are still short of full match fitness.
Midfielder John-Joe O'Toole remains a long-term absentee as he recovers from the cruciate injury he suffered last season.
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