Leaders Brighton extended their lead at the top of npower League One to four points with a 4-0 win which added to the pain for bottom side Plymouth.
A day after Argyle suffered a 10-point deduction for announcing their intention to go in to administration which dropped them to the bottom of the table the visitors were thrashed by the title favourites.
Brighton went ahead through Glenn Murray after 28 minutes and Chris Wood extended the lead with a long-range shot five minutes before half-time. Murray's second three minutes after the break wrapped up the points before Francisco Sandaza added a fourth.
Michael Symes' missed penalty meant Bournemouth lost ground as they were held 0-0 at home by Sheffield Wednesday.
Huddersfield also lost ground as they were held 1-1 at Dagenham & Redbridge, the visitors taking the lead on the half hour with a rare goal from Tom Clarke before Danny Green levelled from the penalty spot after Lee Peltier had handled.
Peterborough also lost ground despite taking the lead early on through George Boyd. Ian Henderson made the home side pay for failing to clear as he levelled with 17 minutes gone to ensure a draw for Colchester.
Four goals in the first half saw Carlisle draw 2-2 at home to Exeter. Carlisle took the lead through Craig Curran but Exeter were ahead before the half hour thanks to a double from Ryan Harley. Francois Zoko brought the home side level on the stroke of half-time to complete the scoring.
Southampton's play-off hopes took a knock as they were held 0-0 at Hartlepool and MK Dons also saw their chances harmed as their home clash with rivals Oldham ended goalless.
Charlie MacDonald wasted little time in the delayed kick-off as he gave Brentford the lead after two minutes but Joss Labadie levelled the scored after 65 minutes for Tranmere before Leon Legge netted a dramatic winner for the home side.
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