Northampton could hand a debut to new signing Guillem Bauza as Macclesfield visit Sixfields.
The Spaniard has joined Gary Johnson's side on a month-to-month contract and will be eligible.
The Cobblers could be without defender Dean Beckwith after he had to be replaced at half-time in the 2-1 defeat at Chesterfield in midweek with a groin strain.
Ben Tozer was dropped by new manager Johnson on Tuesday - with John Johnson moving from right-back to centre-back - but will return if Beckwith is ruled out.
Striker Billy McKay is out for around six weeks after dislocating his elbow and Leon McKenzie is struggling with his knee problem. Midfielder Alistair Slowe has been released.
Full-back Marcus Hall has missed the last two games through illness while defender Craig Hinton has had an injection in a long-standing knee injury and will be out for around a month.
Macclesfield manager Gary Simpson is again without suspended strike duo Ricky Sappleton and Emile Sinclair for the trip.
The pair were sent off along with Wycombe's Dave Winfield during the stormy League Two encounter at Moss Rose, and must now serve the final game of their three-match bans.
Striker Vinny Mukendi could remain sidelined with a knee injury but Simpson will be reluctant to make any changes to his side following the 1-0 home win over Crewe in midweek.
The result eased the Silkmen`s relegation fears and left Simpson in a buoyant mood ahead of the visit to Sixfields.
Simpson said: "The league is so tight that any side that puts together a few games unbeaten will jump up a few places, so that's our aim."
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