Oxford boss Chris Wilder will have Anthony Tonkin and Tom Craddock available for the home clash against Stevenage.
Defender Tonkin missed Saturday's 2-1 win over Port Vale due to a one-match ban, but will come back into contention to face Borough and could replace Stevie Kinniburgh in the starting line-up.
Craddock also missed out against the Valiants due to a knock but Wilder has confirmed the 12-goal striker will return to the squad.
The Us boss has no other injury or suspension problems to worry about and is unlikely to make too many changes.
The means top-scorer James Constable and fellow striker Steve MacLean could remain among the substitutes.
Stevenage boss Graham Westley will be without defender Scott Laird for the trip.
The 22-year-old will complete a one-match ban after being sent off during the second half of Saturday's 1-0 win over promotion-hopefuls Wycombe.
Centre-back Jon Ashton is doubtful with the leg injury that forced him to sit out the win over the Chairboys.
Midfielder Darren Murphy got through 45 minutes unscathed on his first appearance since August and could retain his place in the starting line-up.
Murphy could start alongside John Mousinho, who will keep his place in the team following his match-winning strike at the weekend.
Meanwhile, midfielder Joel Byrom and striker Taiwo Atieno are expected to return to training this week but the game will come too soon for the pair.
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