Lincoln will have new loan signings Tom Kilbey and Elliot Parish at their disposal as they welcome Rotherham to Sincil Bank.
Kilbey, 20, joined Steve Tilson's outfit on an emergency loan from Portsmouth on Thursday and could be handed a starting berth.
The Imps have also secured the loan signing of Aston Villa goalkeeper Parish after Trevor Carson was recalled by parent club Sunderland. Tilson has only goalkeeping coach Paul Musselwhite available as a deputy.
Striker Ben Hutchinson returns to the side after serving a one-match suspension during last weekend's defeat at Stevenage, meaning Scott Spencer will likely return to the bench.
Fellow forward Delroy Facey will miss the rest of the season with a dislocated shoulder.
Top scorer Ashley Grimes fired the Imps' consolation goal against Stevenage and will be key to overcoming the Millers.
Rotherham begin life after Ronnie Moore at Sincil Bank.
The Millers disposed of Moore on Tuesday after a run of poor form and placed Andy Liddell and Paul Warne in charge until the end of the season.
The duo have promised changes to the side following an inept showing during the 5-0 thrashing at Chesterfield, which turned out to be Moore's last game in charge.
Nick Fenton is likely to be available after missing the last two games with a groin problem and could go straight into the side in the heart of defence.
Only goalkeeper Andy Warrington should be safe from the potential chop, with Mark Randall, Omar Daley, Liam Henderson, Danny Harrison, Mark Bradley, Dale Tonge and Tom Newey all hoping for recalls.
Defender Jamie Green could also be involved after he returned from a successful loan spell at Boston.
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