Exeter boss Paul Tisdale will be without defensive duo Stephen Tully and Scott Golbourne for the home clash against Swindon.
Right-back Tully was dismissed after 36 minutes of Saturday's 5-1 thumping at the hands of Colchester following a professional foul on Us striker Ashley Vincent and will complete a one-match ban.
Left-back Golbourne also saw red after committing a foul which led to the hosts taking a 2-1 lead from the penalty spot, and will also complete a one-match ban.
Fellow defenders Billy Jones, Rob Edwards and Scott Bennett will fight it out to replace the duo.
Tisdale has no other injury concerns to worry about.
The Grecians will be looking to get back to winning ways following two successive defeats.
Swindon's Kevin Amankwaah is set to retain his place in the starting line-up for the match.
Amankwaah came in for Michael Timlin in Saturday's 2-1 defeat at Brighton, lining up at right-back with Paul Caddis moving into midfield.
With the change seeming to work for the Robins in providing them with impetus down the right-side and the team performing well against the league leaders, manager Paul Hart is likely to retain the same starting 11.
On-loan Crystal Palace midfielder Alassane N'Diaye came off the bench in stoppage time against the Seagulls for his first appearance for Town and he is likely to start amongst the substitutes again as he is not fully match fit.
Striker Elliot Benyon will also be used again from the bench after he played the last six minutes at the weekend.
Forward Vincent Pericard remains sidelined with a knee injury but is expected to resume full training this week, however, Czech defender Milan Misun, who has yet to make his debut for the club since signing in January, is out for the rest of the season with his knee problem.
Copyright (c) PA Sport 2009, All Rights Reserved.
Do YOU want to write for GiveMeSport? Get started today by signing-up and submitting an article HERE: https://www.givemesport.com/writeforgms