Leyton Orient will check on Ben Chorley ahead of the clash with Plymouth.
The centre-half missed Saturday's 3-1 defeat at Charlton due to a thigh problem and will be assessed prior to kick-off.
Midfielder Matthew Spring is still missing as he serves the second game of the three-match ban he received for a red card against Yeovil last weekend.
Skipper Stephen Dawson (dead leg) and left-back Charlie Daniels (ankle) were carrying injuries ahead of the weekend but both came through the full 90 minutes unscathed.
Back-to-back defeats have put a big dent in Orient's play-off hopes so boss Russell Slade could make changes with Paul-Jose Mpoku and Adam Chambers pushing for places in the starting line-up.
Plymouth will be without Chris Clark and Jim Paterson for the trip.
Midfielder Clark has suffered a knock in training and will miss out, while Paterson has bronchitis to further dent manager Peter Reid's depleted squad.
However, their losses pave the way for Joe Mason and Rory Fallon, who have been suffering from groin and ankle injuries respectively, to claim starting berths.
Onismor Bhasera was recently ruled out for nine months, while the game comes too soon for Luke Summerfield (knee).
The Pilgrims problems have forced Reid to call youngsters Jake Baker and Jed Harper-Penman into the first-team squad, and both could feature.
The former Sunderland boss is confident his side can claim the points at Brisbane Road, saying: "It's going to be a difficult game. Russell Slade has done a terrific job but we go there in the right frame of mind because we know we've got to win games."
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